HitPredict

Interactor 1: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15359284, 15221015, 22773947
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 426 Hs			1 922
+	Hs
		206975 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		1305881 SMAD5_HUMAN (79-424): 5.54e-146: 425: 24.08		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		167384 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125003 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		206970 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		167385 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Dm
		785516 MAD_DROME (72-424): 2.77e-151: 438: 25.48		SUDX_DROME (14-922): 0: 832: 52.00
+	Hs
		125023 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		206971 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		167342 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		206944 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808240 SMAD5_HUMAN (79-424): 5.54e-146: 425: 24.08		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		167395 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Mm
		56823 SMAD7_MOUSE (1-426): 2.83e-174: 495: 98.12		SMUF2_MOUSE (7-381): 5.96e-31: 132: 16.24
+	Hs
		167394 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		206977 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Mm
		192495 SMAD7_MOUSE (1-426): 2.83e-174: 495: 98.12		SMUF1_MOUSE (276-436): 5.09e-16: 84.9: 21.14
+	Hs
		206976 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		1305886 SMAD5_HUMAN (79-424): 5.54e-146: 425: 24.08		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Dm
		785477 MAD_DROME (72-424): 2.77e-151: 438: 25.48		SMUF1_DROME (16-538): 1.82e-25: 115: 13.02