HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: PP4C (P60510)
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
Gene: PPP4C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27391343
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 307
+	Hs
		158435 IKKB_HUMAN (1-743): 0: 583: 50.87		PP4C_HUMAN (1-307): 0: 536: 100.00
+	Hs
		167511 IKKA_HUMAN (1-745): 0: 588: 100.00		PP2AB_HUMAN (6-307): 0: 523: 65.23
+	Hs
		167515 IKKA_HUMAN (1-745): 0: 588: 100.00		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		158442 IKKB_HUMAN (1-743): 0: 583: 50.87		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		167510 IKKA_HUMAN (1-745): 0: 588: 100.00		PP1A_HUMAN (2-304): 0: 517: 43.89
+	Mm
		291448 IKKB_MOUSE (1-743): 0: 584: 49.13		PP1A_MOUSE (2-304): 0: 518: 44.20
+	Hs
		158438 IKKB_HUMAN (1-743): 0: 583: 50.87		PP1A_HUMAN (2-304): 0: 517: 43.89
+	Mm
		956533 TBK1_MOUSE (15-726): 8e-127: 396: 18.68		PP4C_MOUSE (1-307): 0: 536: 100.00
+	Hs
		890962 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PP4C_HUMAN (1-307): 0: 536: 100.00
+	Hs
		930991 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		738035 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		PP1G_HUMAN (1-304): 0: 518: 43.81
+	Hs
		906123 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		PP1A_HUMAN (2-304): 0: 517: 43.89
+	Hs
		915188 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		PP2AB_HUMAN (6-307): 0: 523: 65.23
+	Hs
		625340 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		625180 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PP1G_HUMAN (1-304): 0: 518: 43.81
+	Hs
		625299 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PP1A_HUMAN (2-304): 0: 517: 43.89
+	Hs
		931029 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		PP2AA_HUMAN (6-307): 0: 522: 65.89
+	Hs
		135513 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		PPP6_HUMAN (6-307): 1.53e-148: 420: 61.92
+	Dm
		619883 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		PP2A_DROME (2-307): 0: 522: 64.05
+	Hs
		610705 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		PP1A_HUMAN (2-304): 0: 517: 43.89