Protein: JAK1
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)

Gene: JAK1
Organism: Homo sapiens
Interactions: 244
UniProt ID: P23458

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658649

STAT1
Signal transducer and activator of transcription 1-alpha/beta

10

20

Small-scale

0.976

High

658697

PTN11
Tyrosine-protein phosphatase non-receptor type 11

5

20

Small-scale

0.919

High

193210

SOCS1
Suppressor of cytokine signaling 1

5

20

Small-scale

0.912

High

658648

STAT3
Signal transducer and activator of transcription 3

5

20

Small-scale

0.912

High

658647

IL6RB
Interleukin-6 receptor subunit beta

4

20

Small-scale

0.907

High

658630

JAK1
Tyrosine-protein kinase JAK1

4

19

Small-scale

0.873

High

155911

SOCS3
Suppressor of cytokine signaling 3

3

20

Small-scale

0.866

High

658644

TGFR2
TGF-beta receptor type-2

3

20

High-throughput

0.861

High

658643

IRS1
Insulin receptor substrate 1

3

20

Small-scale

0.834

High

658762

OSMR
Oncostatin-M-specific receptor subunit beta

2

20

High-throughput

0.802

High

296439

STAM2
Signal transducing adapter molecule 2

2

20

Small-scale

0.799

High

658664

JAK3
Tyrosine-protein kinase JAK3

2

19

Small-scale

0.789

High

658678

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.780

High

253298

JAK2
Tyrosine-protein kinase JAK2

2

19

Small-scale

0.768

High

658633

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.768

High

362777

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

623991

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

20

Small-scale

0.754

High

658798

IRS2
Insulin receptor substrate 2

2

20

Small-scale

0.754

High

575808

IL2RB
Interleukin-2 receptor subunit beta

9

20

Small-scale

0.749

High

658651

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.740

High

440370

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.726

High

658757

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

658662

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.713

High

582134

INGR1
Interferon gamma receptor 1

4

19

Small-scale

0.700

High

658631

IL4RA
Interleukin-4 receptor subunit alpha

4

20

Small-scale

0.700

High

572902

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

658681

KC1G2
Casein kinase I isoform gamma-2

1

20

High-throughput

0.691

High

658712

AMHR2
Anti-Muellerian hormone type-2 receptor

1

20

High-throughput

0.691

High

658716

KIF24
Kinesin-like protein KIF24

1

20

High-throughput

0.691

High

658731

INLR1
Interferon lambda receptor 1

3

16

Small-scale

0.673

High

658656

LPAR6
Lysophosphatidic acid receptor 6

3

20

High-throughput

0.667

High

658702

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.665

High

362163

ABL1
Tyrosine-protein kinase ABL1

1

19

Small-scale

0.647

High

410622

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

465409

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.647

High

658650

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.647

High

658699

GAB1
GRB2-associated-binding protein 1

1

20

Small-scale

0.647

High

658709

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.647

High

658659

INAR2
Interferon alpha/beta receptor 2

3

0

Small-scale

0.646

High

622519

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

20

Small-scale

0.646

High

658640

IL3RB
Cytokine receptor common subunit beta

3

20

Small-scale

0.640

High

406867

MAS
Proto-oncogene Mas

2

20

High-throughput

0.628

High

561897

LAMP2
Lysosome-associated membrane glycoprotein 2

2

12

High-throughput

0.628

High

658642

APJ
Apelin receptor

2

19

High-throughput

0.628

High

658707

I13R2
Interleukin-13 receptor subunit alpha-2

2

20

High-throughput

0.628

High

658743

HAVR2
Hepatitis A virus cellular receptor 2

2

5

High-throughput

0.628

High

658795

LAMP3
Lysosome-associated membrane glycoprotein 3

2

12

High-throughput

0.628

High

658680

RACK1
Small ribosomal subunit protein RACK1

2

13

Small-scale

0.624

High

602862

INAR1
Interferon alpha/beta receptor 1

2

20

Small-scale

0.619

High

348974

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.618

High

400288

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

411367

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

439640

INSR
Insulin receptor

1

20

Small-scale

0.618

High

461159

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

466109

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

468083

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

533829

GHR
Growth hormone receptor

1

20

Small-scale

0.618

High

578381

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

599148

IL7RA
Interleukin-7 receptor subunit alpha

1

3

High-throughput

0.618

High

599268

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

20

Small-scale

0.618

High

601174

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

603166

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.618

High

618980

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

Small-scale

0.618

High

658635

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

19

Small-scale

0.618

High

658652

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.618

High

658653

ABL2
Tyrosine-protein kinase ABL2

1

19

Small-scale

0.618

High

658663

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

658665

STAT2
Signal transducer and activator of transcription 2

1

20

Small-scale

0.618

High

658670

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

658671

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

658674

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

658676

1433E
14-3-3 protein epsilon

1

13

Small-scale

0.618

High

658677

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

658679

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

658685

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

658692

TAGL
Transgelin

1

13

Small-scale

0.618

High

658694

KPCZ
Protein kinase C zeta type

1

20

High-throughput

0.618

High

658698

BTK
Tyrosine-protein kinase BTK

1

19

Small-scale

0.618

High

658706

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

658710

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

658723

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

658727

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

658747

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

658761

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.618

High

658771

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

658701

I10R1
Interleukin-10 receptor subunit alpha

2

16

Small-scale

0.613

High

658657

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.602

High

658684

DLK1
Protein delta homolog 1

2

16

High-throughput

0.601

High

658687

MDM2
E3 ubiquitin-protein ligase Mdm2

2

7

Small-scale

0.584

High

658790

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.584

High

484055

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

650052

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.575

High

658735

LRC52
Leucine-rich repeat-containing protein 52

1

20

High-throughput

0.575

High

658763

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.575

High

658772

MANS1
MANSC domain-containing protein 1

2

2

High-throughput

0.574

High

658636

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.571

High

658719

ELP2
Elongator complex protein 2

1

11

Small-scale

0.561

High

658794

CHIP
E3 ubiquitin-protein ligase CHIP

1

16

Small-scale

0.561

High

658637

AGTR1
Type-1 angiotensin II receptor

1

20

High-throughput

0.541

High

658666

TTC3
E3 ubiquitin-protein ligase TTC3

1

16

High-throughput

0.541

High

133225

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.536

High

165902

FFAR1
Free fatty acid receptor 1

1

20

High-throughput

0.536

High

182465

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.536

High

270201

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.536

High

407581

S100B
Protein S100-B

1

9

High-throughput

0.536

High

587561

DESP
Desmoplakin

1

20

High-throughput

0.536

High

658654

EAA3
Excitatory amino acid transporter 3

1

6

High-throughput

0.536

High

658660

PTH2R
Parathyroid hormone 2 receptor

1

10

High-throughput

0.536

High

658672

CXCR4
C-X-C chemokine receptor type 4

1

20

High-throughput

0.536

High

658682

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

658686

EFNB1
Ephrin-B1

1

7

High-throughput

0.536

High

658689

CD83
CD83 antigen

1

2

High-throughput

0.536

High

658690

IL5RA
Interleukin-5 receptor subunit alpha

1

20

Small-scale

0.536

High

658695

VMAT2
Synaptic vesicular amine transporter

1

6

High-throughput

0.536

High

658704

KCNC3
Voltage-gated potassium channel KCNC3

1

15

High-throughput

0.536

High

658714

FILA2
Filaggrin-2

1

11

High-throughput

0.536

High

658722

I20RB
Interleukin-20 receptor subunit beta

1

16

High-throughput

0.536

High

658726

BT2A1
Butyrophilin subfamily 2 member A1

1

15

High-throughput

0.536

High

658736

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.536

High

658737

ARRD4
Arrestin domain-containing protein 4

1

9

High-throughput

0.536

High

658739

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

3

High-throughput

0.536

High

658750

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

6

High-throughput

0.536

High

658754

MRAP2
Melanocortin-2 receptor accessory protein 2

1

3

High-throughput

0.536

High

658756

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.536

High

658759

OPALI
Opalin

1

1

High-throughput

0.536

High

658765

CML1
Chemerin-like receptor 1

1

17

High-throughput

0.536

High

658767

SYT11
Synaptotagmin-11

1

7

High-throughput

0.536

High

658776

CRLF2
Cytokine receptor-like factor 2

1

20

High-throughput

0.536

High

658778

AGO4
Protein argonaute-4

1

2

High-throughput

0.536

High

658786

GPC5B
G-protein coupled receptor family C group 5 member B

1

6

High-throughput

0.536

High

658791

HSPB8
Heat shock protein beta-8

1

8

High-throughput

0.536

High

658792

CLC4A
C-type lectin domain family 4 member A

1

8

High-throughput

0.536

High

658793

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

20

High-throughput

0.536

High

658799

PCDA8
Protocadherin alpha-8

1

9

High-throughput

0.536

High

658801

GPR45
Probable G-protein coupled receptor 45

1

19

High-throughput

0.536

High

658803

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

658752

RN125
E3 ubiquitin-protein ligase RNF125

2

20

Small-scale

0.533

High

155077

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.527

High

658782

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.527

High

658645

BRCA1
Breast cancer type 1 susceptibility protein

1

14

Small-scale

0.515

High

658658

PA24A
Cytosolic phospholipase A2

1

13

Small-scale

0.515

High

658688

IL9R
Interleukin-9 receptor

1

20

Small-scale

0.515

High

658693

UPAR
Urokinase plasminogen activator surface receptor

1

4

Small-scale

0.515

High

658705

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.515

High

658775

IL21R
Interleukin-21 receptor

1

20

Small-scale

0.515

High

658669

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.513

High

658708

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.513

High

658729

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

658730

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.513

High

658746

BSND
Barttin

1

0

High-throughput

0.513

High

658780

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

658789

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

162470

ANM5
Protein arginine N-methyltransferase 5

1

12

Small-scale

0.501

High

658641

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

20

Small-scale

0.501

High

658713

H31T
Histone H3.1t

1

4

Small-scale

0.501

High

658696

CTSL2
CTD small phosphatase-like protein 2

1

5

High-throughput

0.489

High

658738

F174A
Membrane protein FAM174A

1

2

High-throughput

0.489

High

658783

ARL15
ADP-ribosylation factor-like protein 15

1

17

High-throughput

0.489

High

658796

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

18

High-throughput

0.489

High

174484

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

317795

LTN1
E3 ubiquitin-protein ligase listerin

1

2

High-throughput

0.479

High

319403

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

348367

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

349800

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

377967

TNFA
Tumor necrosis factor

1

10

High-throughput

0.479

High

395499

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

413201

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

425314

ISG15
Ubiquitin-like protein ISG15

1

14

High-throughput

0.479

High

446653

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

477098

IL6RA
Interleukin-6 receptor subunit alpha

1

20

Small-scale

0.479

High

543056

UBL4A
Ubiquitin-like protein 4A

1

15

High-throughput

0.479

High

563209

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

Small-scale

0.479

High

571872

TRI27
Zinc finger protein RFP

1

17

Small-scale

0.479

High

596958

TSHR
Thyrotropin receptor

1

20

Small-scale

0.479

High

623107

RO52
E3 ubiquitin-protein ligase TRIM21

1

15

High-throughput

0.479

High

651151

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

658634

PML
Protein PML

1

20

Small-scale

0.479

High

658638

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.479

High

658639

PUR9
Bifunctional purine biosynthesis protein ATIC

1

1

High-throughput

0.479

High

658646

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.479

High

658655

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.479

High

658661

ARRB1
Beta-arrestin-1

1

6

High-throughput

0.479

High

658667

KAD2
Adenylate kinase 2, mitochondrial

1

1

High-throughput

0.479

High

658675

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

658683

ELF3
ETS-related transcription factor Elf-3

1

4

High-throughput

0.479

High

658691

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.479

High

658700

SMAD4
Mothers against decapentaplegic homolog 4

1

5

High-throughput

0.479

High

658718

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

658720

ACD10
Acyl-CoA dehydrogenase family member 10

1

6

High-throughput

0.479

High

658721

I27RA
Interleukin-27 receptor subunit alpha

1

20

Small-scale

0.479

High

658725

ACD11
Acyl-CoA dehydrogenase family member 11

1

6

High-throughput

0.479

High

658732

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

11

Small-scale

0.479

High

658733

TM192
Transmembrane protein 192

1

2

High-throughput

0.479

High

658742

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

8

Small-scale

0.479

High

658748

KAT6A
Histone acetyltransferase KAT6A

1

15

High-throughput

0.479

High

658749

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

658751

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.479

High

658753

TRI11
E3 ubiquitin-protein ligase TRIM11

1

16

Small-scale

0.479

High

658758

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

658760

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

658766

ANM1
Protein arginine N-methyltransferase 1

1

12

High-throughput

0.479

High

658768

REN3B
Regulator of nonsense transcripts 3B

1

9

High-throughput

0.479

High

658770

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

658774

KT3K
Ketosamine-3-kinase

1

1

High-throughput

0.479

High

658777

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

High-throughput

0.479

High

658779

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

6

High-throughput

0.479

High

658781

KIF15
Kinesin-like protein KIF15

1

12

Small-scale

0.479

High

658787

PD1L1
Programmed cell death 1 ligand 1

1

20

Small-scale

0.479

High

658797

NOC2L
Nucleolar complex protein 2 homolog

1

3

Small-scale

0.479

High

658800

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

16

Small-scale

0.479

High

128781

MEN1
Menin

1

0

High-throughput

0.458

High

257339

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

293208

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

658673

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

658711

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

658802

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.458

High

254811

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

12

High-throughput

0.445

High

279561

LAT3
Large neutral amino acids transporter small subunit 3

1

2

High-throughput

0.445

High

388373

B3AT
Band 3 anion transport protein

1

9

High-throughput

0.445

High

529096

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

596456

CTLA4
Cytotoxic T-lymphocyte protein 4

1

6

High-throughput

0.445

High

658632

ACKR3
Atypical chemokine receptor 3

1

20

High-throughput

0.445

High

658668

S12A2
Solute carrier family 12 member 2

1

11

High-throughput

0.445

High

658703

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

658717

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.445

High

658724

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

1

High-throughput

0.445

High

658740

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

5

High-throughput

0.445

High

658745

MOT10
Monocarboxylate transporter 10

1

13

High-throughput

0.445

High

658764

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

5

High-throughput

0.445

High

658769

S22A4
Solute carrier family 22 member 4

1

6

High-throughput

0.445

High

105353

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

658728

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

Small-scale

0.437

High

658755

CCD34
Coiled-coil domain-containing protein 34

1

10

High-throughput

0.437

High

658785

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

541832

TOP1
DNA topoisomerase 1

1

2

Small-scale

0.408

High

658744

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

5

High-throughput

0.407

High

658773

ZDH11
Palmitoyltransferase ZDHHC11

1

10

High-throughput

0.407

High

658734

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

658741

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

658784

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

658788

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

658715

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

87333

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025