HitPredict

Interactor 1: LSM1 (O15116)
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
Gene: LSM1

Interactor 2: LSM4 (Q9Y4Z0)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)
Gene: LSM4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.940

Property	Details
Experiments	27247266, 29395067, 11920408, 33961781, 15231747, 25416956
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, mammalian protein protein interaction trap, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 133 Hs			1 139
+	Hs
		167726 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		167682 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Hs
		167678 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Dm
		1369698 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VKW8_DROME (1-135): 1.09e-46: 150: 57.33
+	Hs
		321444 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM4_HUMAN (1-139): 4.8e-47: 150: 100.00
+	Dm
		1374114 Q9W2K2_DROME (1-124): 3.53e-39: 130: 63.71		Q9VTW6_DROME (1-89): 1.77e-36: 122: 30.00
+	Hs
		1356296 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		LSM4_HUMAN (1-139): 4.8e-47: 150: 100.00
+	Dm
		1374112 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VTW6_DROME (1-89): 1.77e-36: 122: 30.00
+	Hs
		321440 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Sc
		746307 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM2_YEAST (1-88): 3.45e-32: 111: 28.09
+	Hs
		1356292 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		321389 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Sc
		767790 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM4_YEAST (1-98): 9.17e-25: 95.1: 36.11
+	At
		1323437 Q9FI15_ARATH (4-93): 1.78e-25: 98.5: 22.00		SMD1B_ARATH (1-96): 2.54e-33: 114: 23.71
+	Hs
		321390 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		912398 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Hs
		321386 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Hs
		912752 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		911992 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Hs
		911801 RSMN_HUMAN (6-86): 1.43e-24: 95.8: 23.86		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82