HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	29568343, 33961781
Identification Methods	protein complementation assay, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 359
+	Hs
		167757 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		SKAP1_HUMAN (13-359): 1e-98: 298: 42.54
+	Mm
		193097 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		SKAP1_MOUSE (13-359): 1.25e-102: 308: 43.66
+	Hs
		269532 FYB2_HUMAN (108-763): 6.36e-25: 112: 20.17		SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00
+	Hs
		269537 PRAM_HUMAN (203-597): 7.84e-09: 61.1: 9.60		SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00
+	Hs
		1203504 PRAM_HUMAN (203-597): 7.84e-09: 61.1: 9.60		SKAP1_HUMAN (13-359): 1e-98: 298: 42.54
+	Hs
		1154076 NIPBL_HUMAN (74-755): 2.54e-62: 230: 11.11		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		1296378 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		PKHA5_HUMAN (27-326): 3.7e-39: 150: 15.86
+	Hs
		1186090 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		203234 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52
+	Hs
		1186102 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		CD2AP_HUMAN (225-359): 4.02e-22: 99.5: 22.54
+	Hs
		1056986 MDC1_HUMAN (16-730): 7.54e-15: 81.2: 9.50		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		1295403 CHAP1_HUMAN (239-725): 1.33e-12: 73.5: 11.85		PKHA4_HUMAN (83-293): 2.34e-28: 118: 15.28
+	Hs
		203246 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		SH3Y1_HUMAN (159-354): 3.74e-32: 125: 19.70
+	Hs
		855816 TITIN_HUMAN (311-745): 7.86e-09: 61.9: 12.22		VAV2_HUMAN (151-355): 2.94e-28: 118: 15.53
+	Hs
		1300473 PRAM_HUMAN (203-597): 7.84e-09: 61.1: 9.60		ABI2_HUMAN (283-356): 3.54e-19: 90.7: 31.08