HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	17474147, 22074159
Identification Methods	peptide array, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 377
+	Hs
		167730 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		167745 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		167737 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		167751 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		203208 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Mm
		193090 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		FYN_MOUSE (7-173): 7.13e-21: 96: 15.39
+	Hs
		522749 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		554292 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Rn
		192744 SYNJ1_RAT (159-684): 1.66e-12: 73.5: 10.32		SRBS2_RAT (3-162): 4.86e-25: 109: 28.05
+	Hs
		203192 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		924760 PRG4_HUMAN (243-720): 1.33e-15: 83.5: 9.28		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		203230 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84
+	Hs
		517796 NFH_HUMAN (18-409): 7.32e-12: 71.5: 14.54		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		203228 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		1056926 MDC1_HUMAN (16-730): 7.54e-15: 81.2: 9.50		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		203218 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		203241 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76