HitPredict

Interactor 1: IMA6 (O15131)
Importin subunit alpha-6 (Karyopherin subunit alpha-5)
Gene: KPNA5

Interactor 2: NUP50 (Q9UKX7)
Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)
Gene: NUP50

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	25416956, 26186194, 28514442, 32296183, 33961781, unassigned1304, 31515488
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arm~NUP50, Arm_3~NUP50
Common GO terms	GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 539 Hs			1 468
+	Hs
		238747 IMA7_HUMAN (1-539): 3.03e-148: 438: 84.05		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		853751 IMA5_HUMAN (4-539): 5.49e-143: 424: 79.00		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		134978 IMA3_HUMAN (4-539): 9.53e-141: 418: 47.03		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		853515 IMA1_HUMAN (1-539): 3.84e-140: 417: 45.77		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Hs
		1192291 Q7Z726_HUMAN (1-539): 5.09e-140: 416: 45.59		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	At
		1280910 IMPA1_ARATH (3-539): 3.05e-154: 453: 52.03		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		285384 IMPA4_ARATH (3-539): 1.37e-151: 446: 52.50		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		97810 IMPA2_ARATH (3-539): 6.25e-150: 442: 51.66		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		138100 IMPA3_ARATH (3-539): 7.04e-150: 441: 50.65		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		1320502 IMPA6_ARATH (3-539): 6.99e-148: 437: 49.27		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	Hs
		134921 IMA3_HUMAN (4-539): 9.53e-141: 418: 47.03		RGPD4_HUMAN (180-468): 1.25e-39: 154: 16.84
+	Hs
		152769 IMA1_HUMAN (1-539): 3.84e-140: 417: 45.77		RGPD8_HUMAN (196-468): 2.51e-39: 154: 14.34
+	Hs
		63862 IMA3_HUMAN (4-539): 9.53e-141: 418: 47.03		RGPD3_HUMAN (196-468): 4.76e-39: 153: 14.69
+	Hs
		834694 IMA5_HUMAN (4-539): 5.49e-143: 424: 79.00		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Hs
		853440 IMA1_HUMAN (1-539): 3.84e-140: 417: 45.77		RGPD5_HUMAN (196-468): 4.34e-39: 153: 14.34
+	Hs
		134843 IMA3_HUMAN (4-539): 9.53e-141: 418: 47.03		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		131396 IMA4_HUMAN (4-539): 1.11e-139: 415: 45.91		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		134854 IMA3_HUMAN (4-539): 9.53e-141: 418: 47.03		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Hs
		834693 IMA1_HUMAN (1-539): 3.84e-140: 417: 45.77		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Hs
		131404 IMA4_HUMAN (4-539): 1.11e-139: 415: 45.91		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60