HitPredict

Interactor 1: EPHB6 (O15197)
Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)
Gene: EPHB6

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	9707552
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1021 Hs			1 1824
+	Hs
		665569 EPHB2_HUMAN (33-1020): 0: 1130: 45.97		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		876391 EPHA7_HUMAN (16-1013): 0: 1098: 39.67		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		872402 EPHB3_HUMAN (28-1021): 0: 1080: 45.25		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		665186 EPHA2_HUMAN (31-1017): 0: 988: 37.41		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		665663 EPHB2_HUMAN (33-1020): 0: 1130: 45.97		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		1072604 EPHA7_HUMAN (16-1013): 0: 1098: 39.67		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		872713 EPHA4_HUMAN (14-1021): 0: 1097: 39.38		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		665433 EPHA3_HUMAN (30-1021): 0: 1092: 38.87		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		872493 EPHA5_HUMAN (18-1021): 0: 1087: 37.98		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		171337 EPHB6_HUMAN (1-1021): 0: 1080: 100.00		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		665600 EPHB2_HUMAN (33-1020): 0: 1130: 45.97		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		665589 EPHB2_HUMAN (33-1020): 0: 1130: 45.97		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1049958 EPHA7_HUMAN (16-1013): 0: 1098: 39.67		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		1020163 EPHA7_HUMAN (16-1013): 0: 1098: 39.67		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1072546 EPHA7_HUMAN (16-1013): 0: 1098: 39.67		LNX2_HUMAN (908-1089): 8.99e-18: 91.8: 18.13
+	Hs
		872638 EPHA4_HUMAN (14-1021): 0: 1097: 39.38		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		665393 EPHA3_HUMAN (30-1021): 0: 1092: 38.87		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		872431 EPHA5_HUMAN (18-1021): 0: 1087: 37.98		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		665228 EPHA2_HUMAN (31-1017): 0: 988: 37.41		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		600564 EPHA1_HUMAN (25-1010): 0: 918: 36.59		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14