Protein: PP16A
Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)

Gene: PP16A, PPP1R16A
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q96I34

Gene Ontology (top 5):
GO:0004857 - enzyme inhibitor activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0017020 - myosin phosphatase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1151620

TRIP6
Thyroid receptor-interacting protein 6

2

8

High-throughput

0.826

High

1394038

NEK6
Serine/threonine-protein kinase Nek6

2

2

High-throughput

0.783

High

968408

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

5

20

High-throughput

0.725

High

553854

KCRU
Creatine kinase U-type, mitochondrial

2

1

High-throughput

0.700

High

909969

MYOM1
Myomesin-1

2

6

High-throughput

0.700

High

1394030

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

3

High-throughput

0.700

High

1394028

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

16

High-throughput

0.698

High

374854

RASH
GTPase HRas

1

12

High-throughput

0.665

High

650357

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.665

High

786782

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

20

Small-scale

0.654

High

921559

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

0

High-throughput

0.638

High

709151

TPP2
Tripeptidyl-peptidase 2

2

2

High-throughput

0.628

High

1392207

DDX27
Probable ATP-dependent RNA helicase DDX27

1

2

High-throughput

0.625

High

1394033

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

20

High-throughput

0.625

High

216515

SUV91
Histone-lysine N-methyltransferase SUV39H1

2

1

High-throughput

0.606

High

1119770

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

14

High-throughput

0.606

High

1356756

HDAC7
Histone deacetylase 7

2

8

High-throughput

0.606

High

1371237

KAT5
Histone acetyltransferase KAT5

2

2

High-throughput

0.606

High

1366802

PGTA
Geranylgeranyl transferase type-2 subunit alpha

2

6

High-throughput

0.601

High

603331

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.586

High

225664

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.580

High

1315681

CC116
Coiled-coil domain-containing protein 116

2

0

High-throughput

0.580

High

1394043

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

568082

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.560

High

965574

NTF2
Nuclear transport factor 2

2

1

High-throughput

0.553

High

1186900

KR195
Keratin-associated protein 19-5

2

1

High-throughput

0.553

High

1228883

ZFY26
Zinc finger FYVE domain-containing protein 26

2

5

High-throughput

0.553

High

1323663

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

2

2

High-throughput

0.553

High

1392122

CDA7L
Cell division cycle-associated 7-like protein

2

1

High-throughput

0.553

High

1394029

ZN414
Zinc finger protein 414

2

5

High-throughput

0.553

High

1394035

SCNM1
Sodium channel modifier 1

2

1

High-throughput

0.553

High

1394037

UNKL
Putative E3 ubiquitin-protein ligase UNKL

2

5

High-throughput

0.553

High

1164374

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

2

High-throughput

0.541

High

1288709

CAD24
Cadherin-24

1

3

High-throughput

0.541

High

1061824

TLE5
TLE family member 5

1

3

High-throughput

0.523

High

1394041

PUF60
Poly(U)-binding-splicing factor PUF60

1

8

High-throughput

0.518

High

576922

I23O1
Indoleamine 2,3-dioxygenase 1

1

0

High-throughput

0.518

High

1384201

RGMA
Repulsive guidance molecule A

1

0

High-throughput

0.518

High

442443

GELS
Gelsolin

1

6

High-throughput

0.515

High

570562

GFAP
Glial fibrillary acidic protein

1

12

High-throughput

0.515

High

1360722

JPH3
Junctophilin-3

1

3

High-throughput

0.515

High

1394042

UBQL1
Ubiquilin-1

1

3

High-throughput

0.515

High

967914

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

Small-scale

0.508

High

1394040

TFP11
Tuftelin-interacting protein 11

1

2

High-throughput

0.508

High

211506

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

1

High-throughput

0.494

High

702491

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

713128

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.493

High

1369609

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1394032

LZTS2
Leucine zipper putative tumor suppressor 2

1

16

High-throughput

0.481

High

1394039

PHP14
14 kDa phosphohistidine phosphatase

1

1

High-throughput

0.481

High

947252

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

971878

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.479

High

169702

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

5

Small-scale

0.457

High

1232787

Q6FIE5
14 kDa phosphohistidine phosphatase

1

1

High-throughput

0.457

High

1213432

AT7L2
Ataxin-7-like protein 2

1

1

High-throughput

0.439

High

316686

LY6H
Lymphocyte antigen 6H

1

0

High-throughput

0.438

High

1328593

RFLB
Refilin-B

1

0

High-throughput

0.438

High

156485

ACPM
Acyl carrier protein, mitochondrial

2

0

High-throughput

0.316

High

914716

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.316

High

948251

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.316

High

1187438

CC036
Uncharacterized protein C3orf36

2

0

High-throughput

0.316

High

1213404

AVPI1
Arginine vasopressin-induced protein 1

2

0

High-throughput

0.316

High

1220031

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1346688

CA216
UPF0500 protein C1orf216

2

0

High-throughput

0.316

High

1359881

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.316

High

1394031

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

1394034

PBDC1
Protein PBDC1

1

0

High-throughput

0.282

High

47396

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

622248

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

1394036

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025