Protein: MYPT2
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)

Gene: MYPT2, PPP1R12B
Organism: Homo sapiens
Interactions: 63
UniProt ID: O60237

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0004857 - enzyme inhibitor activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

239285

NUAK1
NUAK family SNF1-like kinase 1

2

6

Small-scale

0.789

High

239308

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

6

20

Small-scale

0.739

High

171126

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

18

High-throughput

0.715

High

177143

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

17

High-throughput

0.691

High

239289

ANR17
Ankyrin repeat domain-containing protein 17

1

20

High-throughput

0.691

High

239291

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

19

High-throughput

0.691

High

239298

ANK1
Ankyrin-1

1

19

High-throughput

0.691

High

239305

NOTC1
Neurogenic locus notch homolog protein 1

1

20

High-throughput

0.691

High

239309

ANK2
Ankyrin-2

1

19

High-throughput

0.691

High

239310

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.691

High

239311

ANK3
Ankyrin-3

1

20

High-throughput

0.691

High

239321

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

20

High-throughput

0.691

High

239326

IASPP
RelA-associated inhibitor

1

19

High-throughput

0.691

High

239336

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

19

High-throughput

0.691

High

239339

ANFY1
Rabankyrin-5

1

19

High-throughput

0.691

High

239342

NOTC3
Neurogenic locus notch homolog protein 3

1

20

High-throughput

0.691

High

239343

ASB3
Ankyrin repeat and SOCS box protein 3

1

20

High-throughput

0.691

High

239344

ASB1
Ankyrin repeat and SOCS box protein 1

1

20

High-throughput

0.691

High

239290

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

5

High-throughput

0.667

High

239327

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

17

High-throughput

0.628

High

239312

KGP1
cGMP-dependent protein kinase 1

1

9

Small-scale

0.621

High

239302

CTNB1
Catenin beta-1

1

11

High-throughput

0.618

High

239317

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.618

High

239334

SIK2
Serine/threonine-protein kinase SIK2

1

4

Small-scale

0.618

High

239304

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

20

High-throughput

0.611

High

239337

ANLN
Anillin

2

4

High-throughput

0.611

High

239299

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.594

High

239313

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

19

Small-scale

0.594

High

239332

ZBT18
Zinc finger and BTB domain-containing protein 18

1

20

High-throughput

0.575

High

239292

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

239286

GMDS
GDP-mannose 4,6 dehydratase

1

3

High-throughput

0.536

High

239288

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

12

High-throughput

0.536

High

239300

TPP2
Tripeptidyl-peptidase 2

1

2

High-throughput

0.536

High

239303

MYH9
Myosin-9

1

6

High-throughput

0.536

High

239306

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

10

High-throughput

0.536

High

239307

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

High-throughput

0.536

High

239320

CSN6
COP9 signalosome complex subunit 6

1

2

High-throughput

0.536

High

239323

SYNPO
Synaptopodin

1

10

High-throughput

0.536

High

239325

BBS1
BBSome complex member BBS1

1

1

High-throughput

0.536

High

239328

MY18A
Unconventional myosin-XVIIIa

1

13

High-throughput

0.536

High

239330

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.536

High

239331

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

7

High-throughput

0.536

High

239333

LRRC1
Leucine-rich repeat-containing protein 1

1

2

High-throughput

0.536

High

239338

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

17

High-throughput

0.536

High

239293

GELS
Gelsolin

1

6

High-throughput

0.515

High

239314

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.515

High

239335

ISCU
Iron-sulfur cluster assembly enzyme ISCU

1

0

High-throughput

0.513

High

239340

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

239341

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.513

High

137873

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.479

High

239287

USO1
General vesicular transport factor p115

1

18

High-throughput

0.479

High

239295

HSP7C
Heat shock cognate 71 kDa protein

1

10

Small-scale

0.479

High

239296

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

239297

TPR
Nucleoprotein TPR

1

16

High-throughput

0.479

High

239301

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

5

High-throughput

0.479

High

239316

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

239318

E2F4
Transcription factor E2F4

1

5

High-throughput

0.479

High

239319

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

239322

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.479

High

239329

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

239315

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

4

High-throughput

0.470

High

239324

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High

239294

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025