HitPredict

Interactor 1: P73 (O15350)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: TP73

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 21508668, 9802988, 11238924, 25417702, 9891077, 21930790, 38580884
Identification Methods affinity chromatography technology, two hybrid, pull down, proximity labelling technology
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains P53~P53, P53~P53_tetramer, P53_tetramer~P53_tetramer
Common GO terms GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
and 16 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 636
Hs

1 393
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+ Dr
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024