HitPredict

Interactor 1: P73 (O15350)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: TP73

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

The method score is based on:

Property	Details
Experiments	15454570, 17353261
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001222 - transcription corepressor binding GO:0002039 - p53 binding GO:0005634 - nucleus and 8 others more... GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048714 - positive regulation of oligodendrocyte differentiation GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	636
Hs

1	482

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024