Protein: KMT2B
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)

Gene: KMT2B
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q9UMN6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding
GO:0032259 - methylation
GO:0035097 - histone methyltransferase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458470

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

11

20

Small-scale

0.977

High

1145562

RBBP5
Retinoblastoma-binding protein 5

10

20

Small-scale

0.970

High

998942

H31
Histone H3.1

3

20

Small-scale

0.834

High

1041621

KMT2A
Histone-lysine N-methyltransferase 2A

2

18

Small-scale

0.768

High

965330

WDR5
WD repeat-containing protein 5

17

20

Small-scale

0.764

High

1110192

HDAC1
Histone deacetylase 1

2

19

High-throughput

0.754

High

1250057

WDR82
WD repeat-containing protein 82

2

20

Small-scale

0.754

High

129550

MEN1
Menin

5

6

Small-scale

0.713

High

1130608

NCOA6
Nuclear receptor coactivator 6

4

20

Small-scale

0.694

High

1163288

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1462042

HCFC2
Host cell factor 2

3

20

High-throughput

0.667

High

1258979

H32
Histone H3.2

1

20

Small-scale

0.647

High

913092

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

8

Small-scale

0.646

High

1410404

MEP50
Methylosome protein WDR77

1

19

Small-scale

0.646

High

373484

MYC
Myc proto-oncogene protein

3

13

High-throughput

0.640

High

161525

KMT2D
Histone-lysine N-methyltransferase 2D

1

19

High-throughput

0.618

High

175948

SET1A
Histone-lysine N-methyltransferase SETD1A

1

18

High-throughput

0.618

High

194629

KDM6A
Lysine-specific demethylase 6A

1

20

High-throughput

0.618

High

224397

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

883732

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

980537

H4
Histone H4

1

8

High-throughput

0.618

High

981179

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

1017297

H33
Histone H3.3

1

20

High-throughput

0.618

High

1097630

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.618

High

1220889

RN123
E3 ubiquitin-protein ligase RNF123

1

15

High-throughput

0.618

High

1338285

KMT2C
Histone-lysine N-methyltransferase 2C

1

17

High-throughput

0.618

High

1339036

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1384479

PF21A
PHD finger protein 21A

1

20

High-throughput

0.618

High

1387641

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

17

High-throughput

0.618

High

1454062

CXXC1
CXXC-type zinc finger protein 1

1

19

High-throughput

0.618

High

1454810

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.618

High

1462038

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.618

High

1257169

PAXI1
PAX-interacting protein 1

2

20

Small-scale

0.611

High

1420480

DPY30
Protein dpy-30 homolog

2

7

Small-scale

0.611

High

283156

PSIP1
PC4 and SFRS1-interacting protein

2

8

Small-scale

0.594

High

905513

HCFC1
Host cell factor 1

2

20

Small-scale

0.594

High

1133735

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

397211

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1380885

TRI63
E3 ubiquitin-protein ligase TRIM63

1

11

High-throughput

0.541

High

1419329

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.541

High

832835

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.536

High

995348

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.536

High

998106

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.536

High

1341048

THOC2
THO complex subunit 2

1

20

High-throughput

0.536

High

1364894

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

13

High-throughput

0.526

High

403034

ANXA1
Annexin A1

1

7

High-throughput

0.508

High

405561

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.508

High

616377

RCC1
Regulator of chromosome condensation

1

3

High-throughput

0.508

High

628029

ANXA7
Annexin A7

1

7

High-throughput

0.508

High

1014658

SMAD3
Mothers against decapentaplegic homolog 3

1

14

High-throughput

0.508

High

1109419

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.508

High

1152493

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.508

High

1160617

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

1396151

Z512B
Zinc finger protein 512B

1

8

High-throughput

0.508

High

1086725

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

4

Small-scale

0.501

High

1370874

FUBP2
Far upstream element-binding protein 2

1

8

Small-scale

0.500

High

706350

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

325452

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.486

High

808198

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

927609

ATX1
Ataxin-1

1

0

High-throughput

0.486

High

71486

P20L1
PHD finger protein 20-like protein 1

1

11

High-throughput

0.479

High

143326

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

191159

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

247029

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

284899

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.479

High

339892

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

362409

ABL1
Tyrosine-protein kinase ABL1

1

11

High-throughput

0.479

High

440785

FYN
Tyrosine-protein kinase Fyn

1

11

High-throughput

0.479

High

474371

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

519436

MYB
Transcriptional activator Myb

1

8

High-throughput

0.479

High

590024

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

594137

NCK1
SH2/SH3 adapter protein NCK1

1

11

High-throughput

0.479

High

613225

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

675725

TYY1
Transcriptional repressor protein YY1

1

9

High-throughput

0.479

High

697292

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

714521

PML
Protein PML

1

17

High-throughput

0.479

High

739045

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

769504

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

834092

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

837107

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

855804

CRK
Adapter molecule crk

1

8

High-throughput

0.479

High

862550

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

887328

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.479

High

913822

ZN131
Zinc finger protein 131

1

10

High-throughput

0.479

High

928364

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

944764

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

961890

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.479

High

988030

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

1054820

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.479

High

1088098

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1152760

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1276122

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

1315075

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

1336887

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1338714

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

17

High-throughput

0.479

High

1351197

SP7
Transcription factor Sp7

1

18

High-throughput

0.479

High

1367583

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1390191

MCRS1
Microspherule protein 1

1

4

High-throughput

0.479

High

1405458

FEV
Protein FEV

1

20

High-throughput

0.479

High

1405653

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1413535

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

2

Small-scale

0.479

High

1415301

PHF20
PHD finger protein 20

1

20

High-throughput

0.479

High

1416951

KLF16
Krueppel-like factor 16

1

18

High-throughput

0.479

High

1435968

KAT8
Histone acetyltransferase KAT8

1

5

High-throughput

0.479

High

1436243

CSR2B
Cysteine-rich protein 2-binding protein

1

20

High-throughput

0.479

High

1437169

KANL2
KAT8 regulatory NSL complex subunit 2

1

3

High-throughput

0.479

High

1449161

MBIP1
MAP3K12-binding inhibitory protein 1

1

3

High-throughput

0.479

High

1452480

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1454739

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

1459302

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1461133

RCOR1
REST corepressor 1

1

12

High-throughput

0.479

High

1461536

ZN608
Zinc finger protein 608

1

10

High-throughput

0.479

High

1461643

YETS2
YEATS domain-containing protein 2

1

20

High-throughput

0.479

High

1462039

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

1462040

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

1462041

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

420852

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.464

High

959423

RAP1B
Ras-related protein Rap-1b

1

9

High-throughput

0.464

High

1126665

GRB7
Growth factor receptor-bound protein 7

1

12

High-throughput

0.464

High

1365298

SEPT8
Septin-8

1

5

High-throughput

0.464

High

1250595

DPPA3
Developmental pluripotency-associated protein 3

1

0

High-throughput

0.458

High

1364304

TOPB1
DNA topoisomerase 2-binding protein 1

1

12

Small-scale

0.457

High

861331

MAP1B
Microtubule-associated protein 1B

1

10

Small-scale

0.457

High

1430160

QRIC2
Glutamine-rich protein 2

1

20

Small-scale

0.457

High

1029783

FOXK2
Forkhead box protein K2

1

9

High-throughput

0.445

High

220817

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

1

High-throughput

0.437

High

995897

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.437

High

1201234

SPIN4
Spindlin-4

1

0

High-throughput

0.426

High

1448554

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.417

High

1436765

GHC1
Mitochondrial glutamate carrier 1

1

7

High-throughput

0.407

High

1278594

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

0

High-throughput

0.345

High

1098688

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1159459

NREP
Neuronal regeneration-related protein

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025