HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: BUB1B (O60566)
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
Gene: BUB1B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28985013, 19407811
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 1050
+	Hs
		236923 HDAC1_HUMAN (3-385): 0: 588: 62.92		BUB1B_HUMAN (1-1050): 0: 826: 100.00
+	Hs
		236961 HDAC2_HUMAN (3-422): 0: 580: 58.63		BUB1B_HUMAN (1-1050): 0: 826: 100.00
+	Hs
		211013 HDAC1_HUMAN (3-385): 0: 588: 62.92		BUB1_HUMAN (53-1042): 1.59e-170: 531: 19.04
+	Hs
		177211 HDAC3_HUMAN (1-428): 0: 600: 100.00		AKT1_HUMAN (687-1044): 9.94e-111: 354: 13.46
+	Hs
		1038352 HDAC1_HUMAN (3-385): 0: 588: 62.92		KCC2G_HUMAN (764-985): 5.89e-62: 223: 19.05
+	Hs
		224729 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		KALRN_HUMAN (94-1029): 8.15e-122: 414: 11.68
+	Hs
		160691 HDAC2_HUMAN (3-422): 0: 580: 58.63		AURKA_HUMAN (671-986): 1.25e-38: 151: 16.01
+	Mm
		682135 HDAC6_MOUSE (5-320): 1.83e-105: 338: 23.55		AKT1_MOUSE (641-1044): 6.16e-112: 357: 12.20
+	Hs
		566496 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		KPCA_HUMAN (576-1044): 3.3e-109: 356: 13.75
+	Hs
		682052 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		AKT1_HUMAN (687-1044): 9.94e-111: 354: 13.46
+	Hs
		160825 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		AURKA_HUMAN (671-986): 1.25e-38: 151: 16.01