HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39098523
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PB1~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0044877 - protein-containing complex binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 440
+	Hs
		167891 IKKB_HUMAN (1-743): 0: 588: 50.87		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1108258 TBK1_HUMAN (15-726): 4.13e-127: 397: 18.82		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1107857 MARK2_HUMAN (2-718): 8.98e-125: 393: 15.28		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		667829 CDK2_HUMAN (12-312): 4.39e-124: 374: 23.30		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		605667 KAPCA_HUMAN (3-316): 9.08e-90: 287: 27.41		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		279156 ULK1_HUMAN (7-221): 7.51e-30: 129: 34.50		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1107910 ULK2_HUMAN (15-221): 2.43e-28: 124: 36.28		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		266961 ULK1_MOUSE (7-221): 2.27e-30: 130: 34.50		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		177873 IKKA_HUMAN (1-745): 0: 596: 100.00		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		167898 IKKB_HUMAN (1-743): 0: 588: 50.87		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		1295590 TBK1_HUMAN (15-726): 4.13e-127: 397: 18.82		MIB1_HUMAN (105-233): 3.49e-43: 164: 25.19
+	Mm
		1281844 TBK1_MOUSE (15-726): 5.87e-127: 396: 18.68		MIB1_MOUSE (105-233): 5.54e-43: 163: 25.19
+	Hs
		1383741 TBK1_HUMAN (15-726): 4.13e-127: 397: 18.82		MIB2_HUMAN (106-264): 3.56e-23: 104: 26.09
+	Hs
		343096 TBK1_HUMAN (15-726): 4.13e-127: 397: 18.82		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		342929 MARK2_HUMAN (2-718): 8.98e-125: 393: 15.28		HERC2_HUMAN (120-197): 2.61e-12: 71.3: 32.50
+	Hs
		1128858 TBK1_HUMAN (15-726): 4.13e-127: 397: 18.82		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		605683 KAPCA_HUMAN (3-316): 9.08e-90: 287: 27.41		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78
+	Hs
		279162 ULK1_HUMAN (7-221): 7.51e-30: 129: 34.50		NBR1_HUMAN (80-184): 5.97e-10: 63.6: 24.78