HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	29523541, 16511572, 21148311, 22556425, 24190973, 16511560
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 247
+	Hs
		179702 MDM4_HUMAN (1-490): 0: 692: 100.00		1433E_HUMAN (1-244): 2.03e-141: 398: 63.53
+	Hs
		179713 MDM4_HUMAN (1-490): 0: 692: 100.00		1433F_HUMAN (1-246): 2.51e-135: 382: 86.99
+	Mm
		205235 MDM4_MOUSE (1-490): 0: 678: 83.91		1433G_MOUSE (1-247): 3.17e-139: 392: 100.00
+	Hs
		179677 MDM4_HUMAN (1-490): 0: 692: 100.00		1433B_HUMAN (2-247): 1.92e-109: 317: 75.40
+	Hs
		179706 MDM4_HUMAN (1-490): 0: 692: 100.00		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		179674 MDM4_HUMAN (1-490): 0: 692: 100.00		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		179678 MDM4_HUMAN (1-490): 0: 692: 100.00		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Hs
		990103 MDM2_HUMAN (2-488): 0: 554: 31.56		1433Z_HUMAN (2-245): 2.4e-108: 314: 74.59
+	Hs
		690912 MDM2_HUMAN (2-488): 0: 554: 31.56		1433T_HUMAN (2-245): 5.55e-105: 305: 70.33
+	Hs
		730517 MDM2_HUMAN (2-488): 0: 554: 31.56		1433S_HUMAN (2-245): 1.87e-98: 289: 65.16
+	Mm
		662962 MDM2_MOUSE (2-488): 0: 532: 29.78		1433T_MOUSE (2-245): 3.01e-105: 306: 70.73