HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28514442, 18356162, 16511560
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 245
+	Hs
		179702 MDM4_HUMAN (1-490): 0: 692: 100.00		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		179674 MDM4_HUMAN (1-490): 0: 692: 100.00		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		179677 MDM4_HUMAN (1-490): 0: 692: 100.00		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Hs
		179699 MDM4_HUMAN (1-490): 0: 692: 100.00		1433G_HUMAN (1-240): 2.38e-108: 314: 74.59
+	Hs
		179713 MDM4_HUMAN (1-490): 0: 692: 100.00		1433F_HUMAN (2-240): 1.27e-107: 312: 74.49
+	Hs
		179678 MDM4_HUMAN (1-490): 0: 692: 100.00		1433S_HUMAN (1-237): 8.31e-104: 302: 71.97
+	Mm
		205235 MDM4_MOUSE (1-490): 0: 678: 83.91		1433G_MOUSE (1-240): 2.38e-108: 314: 74.59
+	Hs
		990103 MDM2_HUMAN (2-488): 0: 554: 31.56		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		690912 MDM2_HUMAN (2-488): 0: 554: 31.56		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Mm
		662962 MDM2_MOUSE (2-488): 0: 532: 29.78		1433T_MOUSE (1-245): 9.02e-140: 393: 79.18
+	Hs
		730517 MDM2_HUMAN (2-488): 0: 554: 31.56		1433S_HUMAN (1-237): 8.31e-104: 302: 71.97