HitPredict

Interactor 1: YKT6 (O15498)
Synaptobrevin homolog YKT6 (EC 2.3.1.-)
Gene: YKT6

Interactor 2: STX3 (Q13277)
Syntaxin-3
Gene: STX3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 289
+	Dm
		1098114 Q9W3M8_DROME (1-196): 9.21e-71: 215: 61.74		STX1A_DROME (2-284): 1.93e-73: 228: 55.59
+	At
		1352985 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SYP42_ARATH (37-283): 2.41e-55: 183: 20.57
+	Hs
		180770 YKT6_HUMAN (1-198): 2.95e-72: 218: 100.00		STX11_HUMAN (1-273): 2.64e-52: 174: 29.37
+	At
		812702 VA722_ARATH (22-194): 8.26e-69: 210: 20.43		SY121_ARATH (28-265): 1.04e-53: 179: 22.40
+	At
		1378372 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SY121_ARATH (28-265): 1.04e-53: 179: 22.40
+	Hs
		180894 YKT6_HUMAN (1-198): 2.95e-72: 218: 100.00		STX12_HUMAN (28-270): 8.2e-51: 170: 25.91
+	Mm
		1225102 YKT6_MOUSE (1-198): 1.76e-73: 222: 92.93		STX5_MOUSE (2-266): 6.31e-48: 165: 16.49
+	Rn
		996535 YKT6_RAT (1-198): 8.39e-73: 220: 94.95		STX5_RAT (2-266): 2.9e-48: 165: 16.49
+	At
		249597 YKT61_ARATH (1-198): 5.24e-69: 210: 44.50		SYP41_ARATH (40-283): 1.66e-51: 173: 18.33
+	At
		249598 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SYP41_ARATH (40-283): 1.66e-51: 173: 18.33
+	Dm
		1098015 Q9W3M8_DROME (1-196): 9.21e-71: 215: 61.74		STX5_DROME (2-267): 1.96e-47: 166: 15.59
+	Hs
		178309 YKT6_HUMAN (1-198): 2.95e-72: 218: 100.00		STX7_HUMAN (37-284): 2.99e-48: 163: 25.79
+	At
		1352876 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SYP43_ARATH (34-283): 2.38e-50: 170: 17.90
+	At
		1352937 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SY122_ARATH (27-265): 3.1e-50: 170: 24.70
+	At
		1258650 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SY132_ARATH (7-265): 1.87e-48: 164: 23.25
+	Sc
		731045 YKT6_YEAST (1-198): 9.98e-69: 209: 47.00		SSO2_YEAST (15-277): 2.78e-48: 164: 24.72
+	At
		812689 VA722_ARATH (22-194): 8.26e-69: 210: 20.43		SY111_ARATH (29-265): 6.47e-47: 161: 24.08
+	At
		1114744 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SY111_ARATH (29-265): 6.47e-47: 161: 24.08
+	Sc
		699484 YKT6_YEAST (1-198): 9.98e-69: 209: 47.00		SSO1_YEAST (28-267): 1.98e-47: 161: 24.59
+	At
		955702 VA721_ARATH (22-194): 3.17e-68: 209: 21.51		SYP22_ARATH (40-271): 4.19e-47: 160: 19.67