HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 732
+	Hs
		147473 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		411551 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431627 FRK_HUMAN (48-202): 1.77e-39: 142: 18.13		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		411945 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431507 FER_HUMAN (4-176): 4.51e-37: 138: 15.56		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		181773 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		431451 FGR_HUMAN (64-201): 3.97e-36: 134: 16.89		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		147475 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		411556 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437967 FRK_HUMAN (48-202): 1.77e-39: 142: 18.13		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		411949 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437867 FER_HUMAN (4-176): 4.51e-37: 138: 15.56		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		437823 FGR_HUMAN (64-201): 3.97e-36: 134: 16.89		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Dm
		365472 SRC42_DROME (64-202): 6.56e-39: 141: 19.44		HSP83_DROME (15-732): 0: 1034: 78.41
+	Hs
		411978 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		ENPL_HUMAN (14-701): 0: 898: 46.78
+	Hs
		181871 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		411751 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		412223 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		454838 FGR_HUMAN (64-201): 3.97e-36: 134: 16.89		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		412222 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		H90B4_HUMAN (30-604): 0: 571: 62.61