HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29991678, 10022833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 993
+	Hs
		146603 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		FLT3_HUMAN (1-993): 0: 844: 97.89
+	Hs
		147491 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FLT3_HUMAN (1-993): 0: 844: 97.89
+	Hs
		411619 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FLT3_HUMAN (1-993): 0: 844: 97.89
+	Mm
		193364 SOCS2_MOUSE (37-211): 1.07e-42: 144: 28.57		FLT3_MOUSE (1-991): 0: 783: 84.27
+	Mm
		193336 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		KIT_MOUSE (57-986): 0: 600: 30.08
+	Hs
		181778 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		256847 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		181766 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		CSF1R_HUMAN (66-949): 0: 588: 31.11
+	Mm
		193337 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		CSF1R_MOUSE (55-948): 0: 586: 30.38
+	Hs
		499278 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		KIT_HUMAN (57-986): 0: 594: 30.44
+	Mm
		403545 SOCS6_MOUSE (66-209): 7.1e-39: 141: 26.06		KIT_MOUSE (57-986): 0: 600: 30.08
+	Hs
		499291 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		146585 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		147481 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		411567 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09
+	Dm
		112209 ABL_DROME (14-193): 2.41e-38: 142: 14.06		M9MRE1_DROME (64-545): 2.24e-27: 122: 12.27
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09
+	Hs
		452495 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04
+	Hs
		452375 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04