HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: TCPQ (P50990)
T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)
Gene: CCT8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 548
+	Hs
		899027 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPQ_HUMAN (1-548): 0: 616: 100.00
+	Hs
		188351 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPH_HUMAN (9-538): 0: 564: 26.39
+	Hs
		188212 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		1110033 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPH_HUMAN (9-538): 0: 564: 26.39
+	Hs
		881911 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		882071 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		188210 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPE_HUMAN (2-524): 0: 535: 29.62
+	Hs
		188219 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPD_HUMAN (19-525): 0: 530: 28.24
+	Hs
		188166 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Sp
		149155 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPE_SCHPO (16-527): 0: 606: 30.17
+	Hs
		875949 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPE_HUMAN (2-524): 0: 535: 29.62
+	Hs
		899378 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPD_HUMAN (19-525): 0: 530: 28.24
+	Hs
		610651 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Hs
		876098 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPE_HUMAN (2-524): 0: 535: 29.62
+	Hs
		610808 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Sp
		149068 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPH_SCHPO (1-546): 0: 566: 28.34
+	Sc
		739886 RPD3_YEAST (3-414): 0: 543: 57.07		TCPH_YEAST (7-542): 0: 534: 28.34
+	Sp
		149057 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPQ_SCHPO (1-545): 0: 527: 50.82
+	Sc
		844419 HOS2_YEAST (4-420): 1.1e-174: 497: 50.36		TCPH_YEAST (7-542): 0: 534: 28.34
+	Sc
		865007 HOS2_YEAST (4-420): 1.1e-174: 497: 50.36		TCPQ_YEAST (1-548): 4.92e-163: 477: 45.69