HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24722339
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hist_deacetyl~Histone
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0040029 - epigenetic regulation of gene expression
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 136
+	Mm
		1017380 Q9JM08_MOUSE (1-428): 0: 595: 99.07		H33_MOUSE (1-136): 1.45e-61: 186: 96.32
+	Hs
		998289 HDAC1_HUMAN (3-385): 0: 588: 62.92		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		1109771 HDAC1_HUMAN (3-385): 0: 588: 62.92		H31T_HUMAN (1-136): 9.24e-62: 187: 97.06
+	Hs
		1016836 HDAC1_HUMAN (3-385): 0: 588: 62.92		H33_HUMAN (1-136): 1.45e-61: 186: 96.32
+	Hs
		117244 HDAC1_HUMAN (3-385): 0: 588: 62.92		K7EK07_HUMAN (1-132): 1.26e-59: 181: 96.21
+	Hs
		998626 HDAC2_HUMAN (3-422): 0: 580: 58.63		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		1161972 HDAC2_HUMAN (3-422): 0: 580: 58.63		H31T_HUMAN (1-136): 9.24e-62: 187: 97.06
+	Hs
		1017073 HDAC2_HUMAN (3-422): 0: 580: 58.63		H33_HUMAN (1-136): 1.45e-61: 186: 96.32
+	Hs
		883531 HDAC1_HUMAN (3-385): 0: 588: 62.92		CENPA_HUMAN (9-133): 7.51e-45: 144: 50.00
+	Sc
		739901 RPD3_YEAST (3-414): 0: 543: 57.07		H3_YEAST (1-136): 7.41e-56: 172: 88.97
+	At
		947416 HDA6_ARATH (3-423): 0: 520: 55.32		H33_ARATH (1-136): 4.68e-62: 188: 96.32
+	Sp
		149005 PHD1_SCHPO (3-407): 0: 519: 56.27		H31_SCHPO (1-136): 2.47e-59: 181: 91.91
+	Ce
		196411 HDA1_CAEEL (3-427): 0: 550: 53.92		HCP3_CAEEL (11-131): 2.76e-44: 147: 48.39
+	Sc
		917106 HOS2_YEAST (4-420): 1.1e-174: 497: 50.36		H3_YEAST (1-136): 7.41e-56: 172: 88.97
+	Hs
		998767 HDAC8_HUMAN (6-367): 8.32e-143: 414: 41.71		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		1162030 HDAC8_HUMAN (6-367): 8.32e-143: 414: 41.71		H31T_HUMAN (1-136): 9.24e-62: 187: 97.06
+	Sc
		925462 HDA1_YEAST (4-351): 1.16e-115: 355: 21.56		H3_YEAST (1-136): 7.41e-56: 172: 88.97
+	Hs
		998904 HDAC6_HUMAN (5-320): 3.51e-103: 333: 23.24		H31_HUMAN (1-136): 1.85e-62: 189: 100.00