HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.44 1.00 0.665

The method score is based on:

Property Details
Experiments 22918830
Identification Methods anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Hist_deacetyl~Hist_deacetyl
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001222 - transcription corepressor binding
GO:0003714 - transcription corepressor activity
and 20 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 428
Hs

1 482
+ Mm
+ Rn
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Sc
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 11Aug2025