HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: RBX2 (Q9WTZ1)
RING-box protein 2 (Rbx2) (RING finger protein 7) (Sensitive to apoptosis gene protein)
Gene: Rnf7

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	15601820
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 225 Mm			1 113
+	Hs
		147449 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		146650 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		147569 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		1263837 SOCS4_HUMAN (16-221): 4.62e-42: 149: 19.81		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		181836 SOCS1_HUMAN (17-221): 1.61e-40: 139: 27.89		RBX1_HUMAN (17-112): 8.65e-38: 124: 46.47
+	Hs
		1345543 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		256860 SOCS5_HUMAN (23-221): 1.3e-39: 144: 21.00		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		146699 SOCS7_HUMAN (16-221): 2.78e-38: 141: 25.24		RBX2_HUMAN (1-113): 2e-33: 114: 96.46
+	Hs
		412267 FYN_HUMAN (34-177): 1.34e-35: 133: 20.53		RN149_HUMAN (15-112): 1.9e-18: 80.6: 22.00