HitPredict

Interactor 1: CSN5 (O35864)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) (Kip1 C-terminus-interacting protein 2)
Gene: Cops5

Interactor 2: CSN2 (P61202)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: Cops2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24973710
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~PCI
Common GO terms	GO:0000338 - protein deneddylation GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Mm			1 443
+	Hs
		897288 CSN5_HUMAN (1-334): 4.61e-129: 373: 99.40		CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00
+	Dm
		1277039 CSN5_DROME (6-334): 2.74e-128: 371: 74.47		CSN2_DROME (16-443): 5.59e-115: 345: 83.92
+	At
		1227249 CSN5A_ARATH (1-330): 4.22e-118: 346: 66.17		CSN2_ARATH (12-442): 5.56e-115: 345: 61.20
+	At
		1258867 CSN5B_ARATH (1-331): 2.65e-116: 342: 66.86		CSN2_ARATH (12-442): 5.56e-115: 345: 61.20
+	An
		1124314 CSN5_EMENI (8-332): 1.22e-104: 311: 54.10		CSN2_EMENI (1-440): 6.53e-108: 330: 50.67
+	Mm
		102340 CSN5_MOUSE (1-334): 8.49e-130: 375: 100.00		G3UXW9_MOUSE (17-443): 1.81e-80: 259: 15.39
+	Ce
		136314 CSN5_CAEEL (5-329): 1.83e-107: 319: 56.88		CSN2_CAEEL (17-417): 3.31e-102: 315: 65.93
+	Hs
		1024199 CSN5_HUMAN (1-334): 4.61e-129: 373: 99.40		CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02
+	Mm
		193526 CSN5_MOUSE (1-334): 8.49e-130: 375: 100.00		CSN1_MOUSE (17-443): 1.68e-79: 255: 15.39
+	Hs
		1272576 CSN5_HUMAN (1-334): 4.61e-129: 373: 99.40		CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25
+	Mm
		193509 CSN5_MOUSE (1-334): 8.49e-130: 375: 100.00		CSN4_MOUSE (54-440): 4.16e-70: 229: 16.29
+	Dm
		1358216 CSN5_DROME (6-334): 2.74e-128: 371: 74.47		CSN4_DROME (52-440): 4.52e-70: 229: 15.42
+	At
		1226047 CSN5A_ARATH (1-330): 4.22e-118: 346: 66.17		CSN4_ARATH (73-439): 8.3e-58: 196: 15.21
+	At
		1226055 CSN5B_ARATH (1-331): 2.65e-116: 342: 66.86		CSN4_ARATH (73-439): 8.3e-58: 196: 15.21
+	Dm
		1180711 PSDE_DROME (41-332): 1.74e-81: 251: 31.25		PSD11_DROME (36-442): 4.15e-87: 273: 20.34
+	Ce
		954226 CSN5_CAEEL (5-329): 1.83e-107: 319: 56.88		CSN4_CAEEL (121-443): 2.79e-57: 195: 15.02
+	At
		799472 CSN5A_ARATH (1-330): 4.22e-118: 346: 66.17		CSN1_ARATH (231-442): 2.95e-44: 162: 21.15
+	At
		799480 CSN5B_ARATH (1-331): 2.65e-116: 342: 66.86		CSN1_ARATH (231-442): 2.95e-44: 162: 21.15
+	Ce
		954225 CSN5_CAEEL (5-329): 1.83e-107: 319: 56.88		CSN1_CAEEL (164-427): 4e-24: 107: 14.82
+	An
		1124331 CSN5_EMENI (8-332): 1.22e-104: 311: 54.10		CSN4_EMENI (92-438): 2.32e-23: 103: 14.71