Protein: PDPK1
3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)

Gene: PDPK1
Organism: Homo sapiens
Interactions: 194
UniProt ID: O15530

Gene Ontology (top 5):
GO:0003323 - type B pancreatic cell development
GO:0004674 - protein serine/threonine kinase activity
GO:0004676 - 3-phosphoinositide-dependent protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193510

AKT1
RAC-alpha serine/threonine-protein kinase

11

20

Small-scale

0.971

High

193471

PDPK1
3-phosphoinositide-dependent protein kinase 1

6

20

Small-scale

0.938

High

193557

KPCZ
Protein kinase C zeta type

4

20

Small-scale

0.914

High

122891

SGK1
Serine/threonine-protein kinase Sgk1

4

16

Small-scale

0.882

High

193530

KC1D
Casein kinase I isoform delta

3

14

Small-scale

0.853

High

193522

KPCI
Protein kinase C iota type

3

20

Small-scale

0.849

High

193474

ROCK2
Rho-associated protein kinase 2

3

19

High-throughput

0.839

High

193571

SQSTM
Sequestosome-1

3

3

High-throughput

0.839

High

193619

OSBL8
Oxysterol-binding protein-related protein 8

3

2

High-throughput

0.839

High

193531

KC1E
Casein kinase I isoform epsilon

3

17

Small-scale

0.817

High

193583

CDC37
Hsp90 co-chaperone Cdc37

3

9

High-throughput

0.817

High

193582

PKN2
Serine/threonine-protein kinase N2

2

20

Small-scale

0.800

High

193486

KPCB
Protein kinase C beta type

2

19

Small-scale

0.768

High

193521

CSK
Tyrosine-protein kinase CSK

2

15

High-throughput

0.767

High

193596

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.752

High

193499

KS6B1
Ribosomal protein S6 kinase beta-1

2

19

Small-scale

0.743

High

193538

WDR5
WD repeat-containing protein 5

6

3

Small-scale

0.739

High

193548

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

2

2

High-throughput

0.737

High

193608

LRC59
Leucine-rich repeat-containing protein 59

2

1

High-throughput

0.737

High

193515

SDC2
Syndecan-2

5

2

Small-scale

0.716

High

193555

1433F
14-3-3 protein eta

5

20

Small-scale

0.714

High

193558

KPCD
Protein kinase C delta type

1

19

Small-scale

0.713

High

193581

PKN1
Serine/threonine-protein kinase N1

1

20

Small-scale

0.713

High

193587

PDPK2
Putative 3-phosphoinositide-dependent protein kinase 2

2

19

High-throughput

0.712

High

193612

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.710

High

193565

PAK1
Serine/threonine-protein kinase PAK 1

1

18

Small-scale

0.691

High

193586

EGFLA
Pikachurin

1

6

High-throughput

0.691

High

193637

NRBP
Nuclear receptor-binding protein

1

8

High-throughput

0.691

High

193491

HSP7C
Heat shock cognate 71 kDa protein

4

4

High-throughput

0.691

High

193496

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

Small-scale

0.680

High

193497

SDC1
Syndecan-1

4

2

High-throughput

0.678

High

193513

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.672

High

193540

1433E
14-3-3 protein epsilon

4

13

Small-scale

0.672

High

193542

1433Z
14-3-3 protein zeta/delta

4

20

Small-scale

0.672

High

193503

1433T
14-3-3 protein theta

3

20

Small-scale

0.670

High

193479

MTMR5
Myotubularin-related protein 5

1

1

High-throughput

0.656

High

193535

ZN133
Zinc finger protein 133

1

1

High-throughput

0.656

High

193576

PEA15
Astrocytic phosphoprotein PEA-15

1

1

High-throughput

0.656

High

193645

GIT1
ARF GTPase-activating protein GIT1

1

6

High-throughput

0.656

High

193567

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.656

High

136746

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

3

6

High-throughput

0.650

High

193476

GPC4
Glypican-4

3

3

High-throughput

0.650

High

193488

FGF2
Fibroblast growth factor 2

3

4

High-throughput

0.650

High

193509

SDC4
Syndecan-4

3

2

High-throughput

0.650

High

193517

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

3

3

High-throughput

0.650

High

193489

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.647

High

193527

MK08
Mitogen-activated protein kinase 8

1

18

Small-scale

0.647

High

193532

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

193651

TBL2
Transducin beta-like protein 2

4

5

High-throughput

0.638

High

193514

1433S
14-3-3 protein sigma

3

20

High-throughput

0.633

High

193539

1433G
14-3-3 protein gamma

3

20

High-throughput

0.633

High

193494

CD44
CD44 antigen

3

2

High-throughput

0.624

High

193606

GSLG1
Golgi apparatus protein 1

3

0

High-throughput

0.622

High

193472

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.618

High

193475

ULK1
Serine/threonine-protein kinase ULK1

1

19

Small-scale

0.618

High

193508

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

20

High-throughput

0.618

High

193511

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.618

High

193534

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

Small-scale

0.618

High

193550

KPCE
Protein kinase C epsilon type

1

20

Small-scale

0.618

High

193554

KPCT
Protein kinase C theta type

1

20

Small-scale

0.618

High

193569

ILK
Scaffold protein ILK

1

9

Small-scale

0.618

High

193570

SNTB2
Beta-2-syntrophin

1

2

High-throughput

0.618

High

193590

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

193594

RASF3
Ras association domain-containing protein 3

1

2

High-throughput

0.618

High

193626

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

193630

INCE
Inner centromere protein

1

9

High-throughput

0.618

High

193507

KAIN
Kallistatin

3

1

High-throughput

0.609

High

193578

RBBP5
Retinoblastoma-binding protein 5

2

4

High-throughput

0.601

High

193617

CAR11
Caspase recruitment domain-containing protein 11

2

5

Small-scale

0.600

High

193480

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

2

High-throughput

0.594

High

193520

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

3

1

High-throughput

0.593

High

193537

ECHB
Trifunctional enzyme subunit beta, mitochondrial

3

1

High-throughput

0.593

High

193473

SPOP
Speckle-type POZ protein

1

5

Small-scale

0.578

High

193487

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

5

High-throughput

0.575

High

193500

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

5

High-throughput

0.575

High

193501

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

5

High-throughput

0.575

High

193563

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

6

High-throughput

0.575

High

193577

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

5

High-throughput

0.575

High

193584

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

6

High-throughput

0.575

High

193490

BIP
Endoplasmic reticulum chaperone BiP

2

8

High-throughput

0.571

High

193493

PLAK
Junction plakoglobin

2

5

High-throughput

0.571

High

193495

HSP76
Heat shock 70 kDa protein 6

2

6

High-throughput

0.571

High

193502

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

High-throughput

0.571

High

193516

HSP74
Heat shock 70 kDa protein 4

2

13

High-throughput

0.571

High

193519

HSPA9
Stress-70 protein, mitochondrial

2

17

High-throughput

0.571

High

193525

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

1

High-throughput

0.571

High

193529

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

5

High-throughput

0.571

High

193544

RL38
Large ribosomal subunit protein eL38

2

1

High-throughput

0.571

High

193551

AKA12
A-kinase anchor protein 12

2

2

High-throughput

0.571

High

193560

DHX9
ATP-dependent RNA helicase A

2

2

High-throughput

0.571

High

193564

CAF1B
Chromatin assembly factor 1 subunit B

2

3

High-throughput

0.571

High

193568

MTA1
Metastasis-associated protein MTA1

2

1

High-throughput

0.571

High

193574

FLNC
Filamin-C

2

3

High-throughput

0.571

High

193575

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

2

High-throughput

0.571

High

193601

TBC15
TBC1 domain family member 15

2

3

High-throughput

0.571

High

193602

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.571

High

193604

HS105
Heat shock protein 105 kDa

2

14

High-throughput

0.571

High

193607

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

4

High-throughput

0.571

High

193611

SNX18
Sorting nexin-18

2

4

High-throughput

0.571

High

193620

DDX24
ATP-dependent RNA helicase DDX24

2

13

High-throughput

0.571

High

193635

CAMP3
Calmodulin-regulated spectrin-associated protein 3

2

4

High-throughput

0.571

High

193545

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.561

High

193599

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

3

Small-scale

0.561

High

192668

ARPC5
Actin-related protein 2/3 complex subunit 5

2

0

High-throughput

0.547

High

193546

GTF2I
General transcription factor II-I

2

0

High-throughput

0.547

High

193561

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.547

High

193588

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.547

High

193614

S29A1
Equilibrative nucleoside transporter 1

2

0

High-throughput

0.547

High

193615

TCF25
Ribosome quality control complex subunit TCF25

2

0

High-throughput

0.547

High

164184

NRP1
Neuropilin-1

1

2

High-throughput

0.536

High

193481

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

193506

TPP2
Tripeptidyl-peptidase 2

1

2

High-throughput

0.536

High

193524

CASP3
Caspase-3

1

6

High-throughput

0.536

High

193533

GPC3
Glypican-3

1

3

High-throughput

0.536

High

193552

TGBR3
Transforming growth factor beta receptor type 3

1

1

High-throughput

0.536

High

193585

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

193591

SND1
Staphylococcal nuclease domain-containing protein 1

1

6

High-throughput

0.536

High

193598

TEFF1
Tomoregulin-1

1

2

High-throughput

0.536

High

193640

PA2G4
Proliferation-associated protein 2G4

1

3

High-throughput

0.536

High

193650

NRX3A
Neurexin-3

1

4

High-throughput

0.536

High

193654

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

3

High-throughput

0.536

High

134202

RPOM
DNA-directed RNA polymerase, mitochondrial

2

1

High-throughput

0.521

High

193498

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

2

4

High-throughput

0.521

High

193512

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

2

4

High-throughput

0.521

High

193629

GRPE1
GrpE protein homolog 1, mitochondrial

2

1

High-throughput

0.521

High

193478

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

193547

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

1

Small-scale

0.516

High

193549

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

Small-scale

0.515

High

193526

HD
Huntingtin

1

5

High-throughput

0.515

High

193536

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

193603

JPH3
Junctophilin-3

1

1

High-throughput

0.515

High

190281

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

193579

CDSN
Corneodesmosin

1

0

High-throughput

0.513

High

193605

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

155883

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.508

High

193492

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.508

High

193562

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.508

High

193633

DDIT4
DNA damage-inducible transcript 4 protein

1

1

High-throughput

0.508

High

193639

XPO7
Exportin-7

1

9

High-throughput

0.508

High

193485

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

193572

CUL3
Cullin-3

1

6

Small-scale

0.501

High

193484

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

185053

TELT
Telethonin

1

0

High-throughput

0.486

High

193573

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.486

High

193593

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.486

High

193600

PXL2B
Prostamide/prostaglandin F synthase

1

0

High-throughput

0.486

High

193621

KTBL1
KATNB1-like protein 1

1

0

High-throughput

0.486

High

193628

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

193632

PNO1
RNA-binding protein PNO1

1

0

High-throughput

0.486

High

193644

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.486

High

193642

KLH20
Kelch-like protein 20

1

4

Small-scale

0.481

High

172281

XPO1
Exportin-1

1

9

High-throughput

0.479

High

193477

DFFB
DNA fragmentation factor subunit beta

1

1

High-throughput

0.479

High

193504

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

193505

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

Small-scale

0.479

High

193528

UTRN
Utrophin

1

2

High-throughput

0.479

High

193541

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

Small-scale

0.479

High

193543

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.479

High

193553

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

193580

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

5

Small-scale

0.479

High

193609

Q96BE0
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

193622

ATG5
Autophagy protein 5

1

2

Small-scale

0.479

High

193624

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

Small-scale

0.479

High

193636

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

193649

STRAP
Serine-threonine kinase receptor-associated protein

1

5

Small-scale

0.479

High

193652

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

9

Small-scale

0.479

High

193595

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.458

High

193618

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

193625

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

193523

MTOR
Serine/threonine-protein kinase mTOR

1

18

Small-scale

0.457

High

193483

IGHG1
Immunoglobulin heavy constant gamma 1

1

5

High-throughput

0.445

High

193556

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

10

High-throughput

0.445

High

193559

B2CL1
Bcl-2-like protein 1

1

4

Small-scale

0.445

High

193566

CBLB
E3 ubiquitin-protein ligase CBL-B

1

5

Small-scale

0.445

High

193643

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

8

High-throughput

0.445

High

193597

CDAN1
Codanin-1

1

0

High-throughput

0.438

High

193623

PININ
Pinin

1

0

High-throughput

0.438

High

193631

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

193482

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.437

High

193518

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

193641

PLAK2
PALM2-AKAP2 fusion protein

1

2

High-throughput

0.437

High

193648

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

High-throughput

0.407

High

193638

CBPA4
Carboxypeptidase A4

3

0

High-throughput

0.347

High

193646

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

3

0

High-throughput

0.330

High

193589

F199X
Protein FAM199X

2

0

High-throughput

0.318

High

193634

T161A
Transmembrane protein 161A

2

0

High-throughput

0.298

High

193653

TF3C5
General transcription factor 3C polypeptide 5

2

0

High-throughput

0.298

High

193592

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

193610

SCRN2
Secernin-2

1

0

High-throughput

0.279

Low

193613

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

193616

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.279

Low

193627

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.265

Low

193647

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025