HitPredict

Interactor 1: H2B1O (P23527)
Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)
Gene: H2BC17

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25963833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 904
+	Hs
		832512 H2B2F_HUMAN (1-126): 1.28e-55: 171: 98.41		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		420814 H2B1J_HUMAN (1-126): 5.49e-55: 169: 98.41		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832322 H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832497 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832624 H2B1H_HUMAN (1-126): 3.39e-55: 169: 99.21		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832673 H2B1M_HUMAN (1-126): 3.31e-55: 169: 95.24		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		708414 H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708456 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		707531 H2B1B_HUMAN (1-126): 1.21e-54: 168: 97.62		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708674 H2B2F_HUMAN (1-126): 1.28e-55: 171: 98.41		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		617930 H2B1O_HUMAN (1-126): 1.76e-55: 170: 100.00		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		420809 H2B1J_HUMAN (1-126): 5.49e-55: 169: 98.41		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708596 H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708664 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708719 H2B1H_HUMAN (1-126): 3.39e-55: 169: 99.21		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708749 H2B1M_HUMAN (1-126): 3.31e-55: 169: 95.24		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		627278 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		1055566 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		1055603 H2B1H_HUMAN (1-126): 3.39e-55: 169: 99.21		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		708933 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		MCM7_HUMAN (188-886): 0: 707: 27.35