HitPredict

Interactor 1: STX1A (O16000)
Syntaxin-1A homolog (Uncoordinated protein 64)
Gene: unc-64

Interactor 2: GOSR2 (P41941)
Golgi SNAP receptor complex member 2 homolog memb-1
Gene: memb-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~V-SNARE_C
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0006906 - vesicle fusion GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 291 Ce			1 213
+	Hs
		160272 STX1A_HUMAN (3-284): 2e-75: 233: 63.96		GOSR2_HUMAN (1-210): 3.11e-57: 181: 32.70
+	Dm
		1174545 STX1A_DROME (1-284): 1.56e-74: 231: 66.43		GOSR2_DROME (1-210): 1.08e-50: 165: 32.56
+	Dm
		1174552 STX1A_DROME (1-284): 1.56e-74: 231: 66.43		Q9W0N6_DROME (1-211): 3.57e-48: 159: 15.28
+	Hs
		1159653 STX1A_HUMAN (3-284): 2e-75: 233: 63.96		VTI1B_HUMAN (2-190): 1.57e-44: 149: 15.39
+	Hs
		160261 STX4_HUMAN (3-284): 2.06e-62: 200: 36.90		GOSR2_HUMAN (1-210): 3.11e-57: 181: 32.70
+	Hs
		746226 STX2_HUMAN (3-284): 1.58e-73: 229: 54.42		VTI1B_HUMAN (2-190): 1.57e-44: 149: 15.39
+	At
		1456368 SYP42_ARATH (35-286): 3.97e-52: 175: 18.77		VTI12_ARATH (1-210): 7.25e-58: 183: 10.55
+	At
		265742 SYP41_ARATH (35-285): 1.75e-52: 175: 18.50		VTI12_ARATH (1-210): 7.25e-58: 183: 10.55
+	At
		1456367 SYP43_ARATH (32-285): 4.02e-51: 172: 19.46		VTI12_ARATH (1-210): 7.25e-58: 183: 10.55
+	Hs
		160299 STX12_HUMAN (28-271): 6.95e-51: 170: 21.86		GOSR2_HUMAN (1-210): 3.11e-57: 181: 32.70
+	Hs
		1087330 STX4_HUMAN (3-284): 2.06e-62: 200: 36.90		VTI1B_HUMAN (2-190): 1.57e-44: 149: 15.39
+	Mm
		313463 Q8BH40_MOUSE (37-289): 2.23e-56: 184: 23.05		VTI1A_MOUSE (1-213): 1.56e-50: 164: 17.43
+	Mm
		1296525 Q8BH40_MOUSE (37-289): 2.23e-56: 184: 23.05		Q91XH6_MOUSE (2-210): 8.62e-50: 163: 15.81
+	At
		265743 SYP41_ARATH (35-285): 1.75e-52: 175: 18.50		VTI11_ARATH (1-192): 3.1e-53: 171: 12.06
+	Hs
		1100732 STX3_HUMAN (3-265): 6.62e-60: 194: 57.96		VTI1B_HUMAN (2-190): 1.57e-44: 149: 15.39
+	At
		1456369 SYP43_ARATH (32-285): 4.02e-51: 172: 19.46		VTI11_ARATH (1-192): 3.1e-53: 171: 12.06
+	Mm
		267003 STX7_MOUSE (37-289): 2.54e-54: 178: 23.05		VTI1B_MOUSE (2-210): 1.07e-49: 163: 15.81
+	Hs
		160910 STX16_HUMAN (4-265): 6.49e-52: 174: 20.91		VTI1A_HUMAN (1-210): 2.17e-48: 159: 17.29
+	Hs
		1294804 STX12_HUMAN (28-271): 6.95e-51: 170: 21.86		VTI1A_HUMAN (1-210): 2.17e-48: 159: 17.29
+	Dm
		84849 STX1A_DROME (1-284): 1.56e-74: 231: 66.43		B7Z0M0_DROME (108-190): 1.26e-14: 69.3: 22.89