HitPredict

Interactor 1: UB2R2 (Q712K3)
Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)
Gene: UBE2R2

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	25900982, 25515538, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~WD40
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 238 Hs			1 542
+	Hs
		828051 UB2R1_HUMAN (1-238): 4.37e-90: 266: 79.41		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		828061 UB2R1_HUMAN (1-238): 4.37e-90: 266: 79.41		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		895947 UB2D3_HUMAN (8-167): 3.59e-70: 213: 29.81		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1174554 UB2R2_HUMAN (1-238): 1.22e-81: 245: 100.00		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		849492 UB2D1_HUMAN (8-167): 2.78e-71: 216: 31.68		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		919912 UB2D2_HUMAN (8-167): 2.85e-71: 216: 29.19		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		895959 UB2D3_HUMAN (8-167): 3.59e-70: 213: 29.81		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		827995 UB2R1_HUMAN (1-238): 4.37e-90: 266: 79.41		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Dm
		218245 UBCD1_DROME (8-167): 1.18e-70: 214: 30.44		O44382_DROME (320-537): 1.23e-57: 202: 30.32
+	Hs
		827922 UB2R1_HUMAN (1-238): 4.37e-90: 266: 79.41		TBL3_HUMAN (237-531): 4.06e-24: 108: 24.46
+	Hs
		828056 UB2R1_HUMAN (1-238): 4.37e-90: 266: 79.41		FBXW2_HUMAN (357-517): 4.14e-24: 106: 27.59
+	Hs
		1163056 UB2D4_HUMAN (8-167): 7.92e-72: 217: 31.68		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17
+	Hs
		849344 UB2D1_HUMAN (8-167): 2.78e-71: 216: 31.68		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17
+	Hs
		919755 UB2D2_HUMAN (8-167): 2.85e-71: 216: 29.19		TRAF7_HUMAN (353-522): 1.18e-28: 122: 27.17
+	Hs
		919901 UB2D2_HUMAN (8-167): 2.85e-71: 216: 29.19		FBXW2_HUMAN (357-517): 4.14e-24: 106: 27.59
+	Sc
		539467 UBC3_YEAST (5-235): 3.47e-69: 216: 35.04		MET30_YEAST (429-535): 5.29e-19: 92.7: 26.85
+	Sc
		431114 UBC3_YEAST (5-235): 3.47e-69: 216: 35.04		CDC4_YEAST (438-540): 1.53e-17: 88.1: 22.86
+	At
		189083 UBC28_ARATH (8-167): 3.29e-70: 213: 31.68		GBLPA_ARATH (246-470): 1e-11: 68.2: 24.81
+	At
		188985 UBC10_ARATH (8-167): 1.42e-69: 211: 31.68		GBLPA_ARATH (246-470): 1e-11: 68.2: 24.81
+	At
		188986 UBC11_ARATH (8-167): 1.77e-69: 211: 32.92		GBLPA_ARATH (246-470): 1e-11: 68.2: 24.81