HitPredict

Interactor 1: SI1L1 (O43166)
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
Gene: SIPA1L1

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, Rap_GAP~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1804 Hs			1 196
+	Hs
		916041 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		230233 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		230232 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Dm
		776929 X2JDH0_DROME (4-825): 0: 636: 23.74		RAC1_DROME (1-196): 1.58e-77: 231: 53.06
+	Dm
		776932 X2JJU0_DROME (4-825): 0: 636: 23.74		RAC1_DROME (1-196): 1.58e-77: 231: 53.06
+	Hs
		835036 TSC2_HUMAN (103-864): 2.82e-172: 572: 14.02		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		915714 RGPA2_HUMAN (300-839): 3.18e-132: 458: 16.90		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		951036 RGPA2_HUMAN (300-839): 3.18e-132: 458: 16.90		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		564550 RGPA2_HUMAN (300-839): 3.18e-132: 458: 16.90		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		925359 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900583 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915756 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		951081 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		892432 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		894131 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		564573 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120494 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		297812 K0754_HUMAN (1315-1795): 2.01e-29: 131: 7.63		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		297809 K0754_HUMAN (1315-1795): 2.01e-29: 131: 7.63		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		120250 K0754_HUMAN (1315-1795): 2.01e-29: 131: 7.63		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98