HitPredict

Interactor 1: SI1L1 (O43166)
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
Gene: SIPA1L1

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 29395067, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1804 Hs			1 669
+	Hs
		196381 SI1L1_HUMAN (1-1804): 0: 1398: 100.00		LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62
+	Hs
		1310197 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		196455 SI1L1_HUMAN (1-1804): 0: 1398: 100.00		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		1350316 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06
+	Hs
		165788 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		N4BP3_HUMAN (17-640): 5.23e-34: 139: 27.16
+	Hs
		230555 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62
+	Hs
		1145965 SI1L2_HUMAN (1-1802): 0: 1277: 47.91		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		230273 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		230186 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62
+	Hs
		230265 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		230253 SI1L3_HUMAN (9-1797): 0: 1005: 44.00		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Rn
		835139 TSC2_RAT (103-864): 0: 639: 12.70		TSC1_RAT (48-630): 5.02e-27: 119: 13.44
+	Mm
		1142070 TSC2_MOUSE (103-864): 0: 605: 13.23		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		148885 RGPA2_HUMAN (300-839): 3.18e-132: 458: 16.90		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		1061846 RGPA1_HUMAN (345-840): 5.8e-113: 401: 17.00		SLMAP_HUMAN (328-641): 1.08e-09: 63.9: 19.94
+	Mm
		1112023 Q3TQ10_MOUSE (643-864): 5.63e-82: 271: 20.17		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		1291406 SIPA1_HUMAN (1484-1790): 6.72e-15: 82.9: 18.97		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		1186077 MICA3_HUMAN (1083-1731): 3.09e-13: 77.5: 12.16		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		149481 PCLO_HUMAN (1009-1740): 1.16e-11: 72.7: 11.66		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36