Protein: KPYK1
Pyruvate kinase I (EC 2.7.1.40) (PK-1)

Gene: KPYK1, pykF
Organism: Escherichia coli K-12
Interactions: 46
UniProt ID: P0AD61

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004743 - pyruvate kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

499591

KPYK1
Pyruvate kinase I

2

14

Small-scale

0.768

High

480586

PFLB
Formate acetyltransferase 1

1

1

High-throughput

0.536

High

491075

DNAK
Chaperone protein DnaK

1

6

High-throughput

0.536

High

491429

IF2
Translation initiation factor IF-2

1

3

High-throughput

0.536

High

499596

RS1
Small ribosomal subunit protein bS1

1

1

High-throughput

0.536

High

499597

SYY
Tyrosine--tRNA ligase

1

1

High-throughput

0.536

High

499609

YHES
Probable ATP-binding protein YheS

1

1

High-throughput

0.536

High

368278

CYAA
Adenylate cyclase

1

0

High-throughput

0.513

High

421039

FUMC
Fumarate hydratase class II

1

0

High-throughput

0.513

High

491618

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.513

High

498499

DEOD
Purine nucleoside phosphorylase DeoD-type

1

0

High-throughput

0.513

High

499599

AMPP
Xaa-Pro aminopeptidase

1

0

High-throughput

0.513

High

499600

NADE
NH(3)-dependent NAD(+) synthetase

1

0

High-throughput

0.513

High

499611

MBHT
Hydrogenase-2 small chain

1

0

High-throughput

0.513

High

499376

RBSR
Ribose operon repressor

1

1

High-throughput

0.489

High

493382

RS13
Small ribosomal subunit protein uS13

1

1

High-throughput

0.479

High

493572

RS19
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

494936

TIG
Trigger factor

1

1

High-throughput

0.479

High

499050

DBHA
DNA-binding protein HU-alpha

1

1

High-throughput

0.479

High

499105

DBHB
DNA-binding protein HU-beta

1

1

High-throughput

0.479

High

499598

MURF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

1

1

High-throughput

0.479

High

492598

RL19
Large ribosomal subunit protein bL19

1

0

High-throughput

0.458

High

492720

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

493152

RL9
Large ribosomal subunit protein bL9

1

0

High-throughput

0.458

High

497485

RL13
Large ribosomal subunit protein uL13

1

0

High-throughput

0.458

High

498350

CISY
Citrate synthase

1

0

Small-scale

0.458

High

498638

EXBB
Biopolymer transport protein ExbB

1

0

High-throughput

0.458

High

499592

YIBL
Uncharacterized protein YibL

1

0

High-throughput

0.458

High

499593

RL16
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

499594

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

499595

RL17
Large ribosomal subunit protein bL17

1

0

High-throughput

0.458

High

499601

NRDD
Anaerobic ribonucleoside-triphosphate reductase

1

0

High-throughput

0.458

High

499604

RLUB
Ribosomal large subunit pseudouridine synthase B

1

0

High-throughput

0.458

High

499606

RL2
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

499607

RL24
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

499608

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

499610

RL25
Large ribosomal subunit protein bL25

1

0

High-throughput

0.458

High

499612

RLMF
Ribosomal RNA large subunit methyltransferase F

1

0

High-throughput

0.458

High

496055

BLC
Outer membrane lipoprotein Blc

1

1

High-throughput

0.437

High

496126

PA1
Phospholipase A1

1

0

High-throughput

0.279

Low

499602

LPTD
LPS-assembly protein LptD

1

0

High-throughput

0.279

Low

499603

PDEC
Probable cyclic di-GMP phosphodiesterase PdeC

1

0

High-throughput

0.279

Low

499605

YRAI
Probable fimbrial chaperone YraI

1

0

High-throughput

0.279

Low

499613

SXY
Protein Sxy

1

0

High-throughput

0.279

Low

499614

GFCD
Uncharacterized lipoprotein GfcD

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025