Interactor 1: KPYR (P30613)
Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)
Gene: PKLR

Interactor 2: KPYR (P30613)
Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)
Gene: PKLR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 31839598
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK~PK, PK~PK_C, PK_C~PK_C
Common GO terms GO:0000287 - magnesium ion binding
GO:0001666 - response to hypoxia
GO:0004743 - pyruvate kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 15 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 574
Hs

1 574
+ Hs
+ Hs
+ Rn
+ Oc
+ Ce
+ Ce
+ Ce
+ Ce
+ Sc
+ Sc
+ At
+ At
+ Ec
+ Zm

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Last updated: 11Aug2025