HitPredict

Interactor 1: TET3 (O43151)
Methylcytosine dioxygenase TET3 (EC 1.14.11.80)
Gene: TET3

Interactor 2: NFIC (P08651)
Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Gene: NFIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39617063
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1795 Hs			1 508
+	Hs
		207960 TET3_HUMAN (1-1795): 0: 1521: 100.00		NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73
+	Hs
		207957 TET3_HUMAN (1-1795): 0: 1521: 100.00		NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20
+	Hs
		142727 TET3_HUMAN (1-1795): 0: 1521: 100.00		NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47
+	Hs
		474138 TET1_HUMAN (1568-1795): 7.16e-64: 243: 39.83		NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00
+	Hs
		474063 TET2_HUMAN (1590-1795): 4.82e-58: 224: 49.29		NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00
+	Hs
		1133471 TET2_HUMAN (1590-1795): 4.82e-58: 224: 49.29		NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73
+	Hs
		1087879 TET1_HUMAN (1568-1795): 7.16e-64: 243: 39.83		NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20
+	Hs
		143128 TET1_HUMAN (1568-1795): 7.16e-64: 243: 39.83		NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47
+	Hs
		1087806 TET2_HUMAN (1590-1795): 4.82e-58: 224: 49.29		NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20
+	Hs
		143054 TET2_HUMAN (1590-1795): 4.82e-58: 224: 49.29		NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47
+	Hs
		473987 MDC1_HUMAN (127-880): 3.94e-20: 100: 10.23		NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00
+	Hs
		474133 KMT2C_HUMAN (443-939): 4.14e-10: 67.4: 9.90		NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00
+	Hs
		161396 KMT2D_HUMAN (139-936): 4.88e-09: 64: 9.61		NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00
+	Hs
		1133540 KMT2C_HUMAN (443-939): 4.14e-10: 67.4: 9.90		NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73
+	Hs
		1087875 KMT2C_HUMAN (443-939): 4.14e-10: 67.4: 9.90		NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20
+	Hs
		143124 KMT2C_HUMAN (443-939): 4.14e-10: 67.4: 9.90		NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47
+	Hs
		142711 KMT2D_HUMAN (139-936): 4.88e-09: 64: 9.61		NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47
+	Dm
		119660 M9PB30_DROME (4-622): 3.06e-30: 134: 12.02		M9PB30_DROME (184-502): 9.76e-09: 60.3: 12.42
+	Hs
		667305 MDC1_HUMAN (127-880): 3.94e-20: 100: 10.23		RPB1_HUMAN (374-496): 2.4e-09: 62.2: 20.33
+	Mm
		1455913 PCLO_MOUSE (429-974): 1.59e-14: 82.1: 10.11		PCLO_MOUSE (184-507): 7.72e-14: 76.9: 9.68