Protein: TET2
Methylcytosine dioxygenase TET2 (EC 1.14.11.80)

Gene: TET2
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q6N021

Gene Ontology (top 5):
GO:0002521 - leukocyte differentiation
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

185775

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

5

5

Small-scale

0.727

High

1144375

NONO
Non-POU domain-containing octamer-binding protein

3

5

High-throughput

0.662

High

971647

1433E
14-3-3 protein epsilon

3

1

Small-scale

0.656

High

990357

1433Z
14-3-3 protein zeta/delta

3

10

Small-scale

0.656

High

966471

1433G
14-3-3 protein gamma

3

10

Small-scale

0.650

High

691128

1433T
14-3-3 protein theta

3

10

Small-scale

0.633

High

1236140

EGLN3
Prolyl hydroxylase EGLN3

2

3

Small-scale

0.611

High

1049424

1433F
14-3-3 protein eta

3

10

Small-scale

0.593

High

407866

SEMG1
Semenogelin-1

2

0

High-throughput

0.585

High

474063

NFIC
Nuclear factor 1 C-type

2

10

High-throughput

0.584

High

624510

WT1
Wilms tumor protein

1

4

Small-scale

0.578

High

1236146

DCAF1
DDB1- and CUL4-associated factor 1

1

4

Small-scale

0.561

High

223540

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

1

High-throughput

0.552

High

1006851

PHC1
Polyhomeotic-like protein 1

1

1

High-throughput

0.552

High

1151258

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.552

High

1158041

HLF
Hepatic leukemia factor

1

2

High-throughput

0.552

High

1236124

RAI1
Retinoic acid-induced protein 1

1

1

High-throughput

0.552

High

1236125

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.549

High

729947

1433B
14-3-3 protein beta/alpha

1

10

High-throughput

0.536

High

1236129

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

168936

TFEC
Transcription factor EC

1

0

High-throughput

0.529

High

351118

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.529

High

604832

HXB9
Homeobox protein Hox-B9

1

0

High-throughput

0.529

High

838369

STA5A
Signal transducer and activator of transcription 5A

1

0

High-throughput

0.529

High

908755

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.529

High

938165

PKNX1
Homeobox protein PKNOX1

1

0

High-throughput

0.529

High

1121422

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.529

High

1153969

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.529

High

1155294

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.529

High

1236130

ZCH14
Zinc finger CCHC domain-containing protein 14

1

0

High-throughput

0.529

High

171080

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.518

High

714197

PML
Protein PML

1

1

Small-scale

0.515

High

1236139

N62CL
Nucleoporin-62 C-terminal-like protein

1

1

High-throughput

0.489

High

141531

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

143054

NFIB
Nuclear factor 1 B-type

1

10

High-throughput

0.479

High

341596

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

352167

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.479

High

390904

TRFE
Serotransferrin

1

1

Small-scale

0.479

High

391034

TRFL
Lactotransferrin

1

1

Small-scale

0.479

High

408936

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

426986

IL6
Interleukin-6

1

1

Small-scale

0.479

High

468496

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.479

High

537350

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

538415

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

600830

HSP76
Heat shock 70 kDa protein 6

1

2

Small-scale

0.479

High

729314

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

Small-scale

0.479

High

730676

1433S
14-3-3 protein sigma

1

10

High-throughput

0.479

High

761426

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

772859

MYH9
Myosin-9

1

2

Small-scale

0.479

High

773206

MYH10
Myosin-10

1

2

Small-scale

0.479

High

775861

HNF1B
Hepatocyte nuclear factor 1-beta

1

1

High-throughput

0.479

High

822718

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

872437

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

886956

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

905423

HCFC1
Host cell factor 1

1

2

Small-scale

0.479

High

952896

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

980849

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

Small-scale

0.479

High

1048005

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1087806

NFIA
Nuclear factor 1 A-type

1

10

High-throughput

0.479

High

1112879

CUL2
Cullin-2

1

4

Small-scale

0.479

High

1118721

KLF5
Krueppel-like factor 5

1

1

High-throughput

0.479

High

1133471

NFIX
Nuclear factor 1 X-type

1

10

High-throughput

0.479

High

1157764

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

1197512

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

1236122

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1236131

RBP56
TATA-binding protein-associated factor 2N

1

2

Small-scale

0.479

High

1236135

SOX7
Transcription factor SOX-7

1

1

High-throughput

0.479

High

1236138

EGLN1
Egl nine homolog 1

1

3

Small-scale

0.479

High

1236143

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.479

High

1236147

DNM3A
DNA

1

1

Small-scale

0.479

High

210024

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.458

High

225029

TLX3
T-cell leukemia homeobox protein 3

1

0

High-throughput

0.458

High

228489

LANC1
Glutathione S-transferase LANCL1

1

0

Small-scale

0.458

High

349126

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

358710

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.458

High

372305

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

390076

ALBU
Albumin

1

0

Small-scale

0.458

High

414031

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

445922

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

456760

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

457501

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

520135

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

540889

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.458

High

550328

PABP1
Polyadenylate-binding protein 1

1

0

Small-scale

0.458

High

552277

ADT3
ADP/ATP translocase 3

1

0

Small-scale

0.458

High

587486

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

623390

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

671808

ZA2G
Zinc-alpha-2-glycoprotein

1

0

Small-scale

0.458

High

925934

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

Small-scale

0.458

High

948438

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.458

High

965026

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

970660

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

972886

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

996208

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.458

High

1056616

PAX8
Paired box protein Pax-8

1

0

High-throughput

0.458

High

1057180

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

1147050

ELOC
Elongin-C

1

0

Small-scale

0.458

High

1147177

ELOB
Elongin-B

1

0

Small-scale

0.458

High

1160858

TBR1
T-box brain protein 1

1

0

High-throughput

0.458

High

1235638

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.458

High

1236127

SP7
Transcription factor Sp7

1

0

High-throughput

0.458

High

1236132

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

High-throughput

0.458

High

1236133

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

1236134

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1236136

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1236142

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

1236145

COE1
Transcription factor COE1

1

0

Small-scale

0.458

High

1236148

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

529964

TAU
Microtubule-associated protein tau

1

3

Small-scale

0.445

High

903395

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

Small-scale

0.445

High

1236126

SMRC2
SWI/SNF complex subunit SMARCC2

1

5

Small-scale

0.445

High

295193

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

High-throughput

0.437

High

447782

TPM3
Tropomyosin alpha-3 chain

1

2

Small-scale

0.437

High

464169

TPM2
Tropomyosin beta chain

1

2

Small-scale

0.437

High

482915

TPM1
Tropomyosin alpha-1 chain

1

2

Small-scale

0.437

High

618703

ML12A
Myosin regulatory light chain 12A

1

1

Small-scale

0.437

High

666758

MYL9
Myosin regulatory light polypeptide 9

1

1

Small-scale

0.437

High

801375

HSPA9
Stress-70 protein, mitochondrial

1

3

Small-scale

0.437

High

996476

ACTS
Actin, alpha skeletal muscle

1

1

Small-scale

0.437

High

996728

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.437

High

1236123

MYH14
Myosin-14

1

2

Small-scale

0.437

High

1236128

BPIB1
BPI fold-containing family B member 1

1

1

Small-scale

0.437

High

1236141

BPIA1
BPI fold-containing family A member 1

1

1

Small-scale

0.437

High

1236121

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.426

High

1236137

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

890128

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.288

High

442365

GELS
Gelsolin

1

0

High-throughput

0.268

Low

650232

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

247126

TBCD4
TBC1 domain family member 4

1

0

Small-scale

0.265

Low

293850

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

294869

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

Small-scale

0.249

Low

387280

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.249

Low

387848

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

Small-scale

0.249

Low

474751

VIME
Vimentin

1

0

Small-scale

0.249

Low

483123

CLCA
Clathrin light chain A

1

0

Small-scale

0.249

Low

532674

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.249

Low

643499

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

Small-scale

0.249

Low

705410

GRN
Progranulin

1

0

Small-scale

0.249

Low

767454

RADI
Radixin

1

0

High-throughput

0.249

Low

942682

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

Small-scale

0.249

Low

952581

MYL6
Myosin light polypeptide 6

1

0

Small-scale

0.249

Low

963191

LYSC
Lysozyme C

1

0

Small-scale

0.249

Low

1010648

DCD
Dermcidin

1

0

Small-scale

0.249

Low

1014908

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.249

Low

1026082

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.249

Low

1143160

PLEC
Plectin

1

0

Small-scale

0.249

Low

1236144

CALL5
Calmodulin-like protein 5

1

0

Small-scale

0.249

Low

87489

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025