HitPredict

Interactor 1: NFIC (P08651)
Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Gene: NFIC

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 39617063
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 2089
+	Hs
		473829 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		667305 RPB1_HUMAN (374-496): 2.4e-09: 62.2: 20.33		MDC1_HUMAN (1-2089): 0: 680: 100.00
+	Hs
		473849 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54
+	Hs
		799121 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		799047 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		474083 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11
+	Hs
		142874 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		1133487 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11
+	Hs
		142888 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54
+	Hs
		1087822 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11
+	Hs
		143071 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11
+	Hs
		474061 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38
+	Hs
		1133469 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38
+	Hs
		1133484 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		SRCAP_HUMAN (537-1551): 5.03e-20: 100: 10.68
+	Hs
		1133624 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		MINT_HUMAN (224-1896): 3.16e-16: 88.1: 11.94
+	Hs
		1087804 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38
+	Hs
		143052 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38
+	Hs
		667200 RPB1_HUMAN (374-496): 2.4e-09: 62.2: 20.33		BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23
+	Hs
		875814 RERE_HUMAN (185-495): 5.5e-30: 126: 13.87		PRC2A_HUMAN (609-1919): 1.32e-13: 79.2: 9.07
+	Mm
		1455913 PCLO_MOUSE (184-507): 7.72e-14: 76.9: 9.68		PCLO_MOUSE (125-1809): 6.85e-09: 63.8: 8.67