HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 802
+	Hs
		557606 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR4_HUMAN (13-802): 0: 750: 100.00
+	Hs
		208983 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		209018 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA4_HUMAN (4-776): 0: 582: 19.47
+	Hs
		208996 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		557643 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHA5_HUMAN (4-771): 0: 580: 18.81
+	Hs
		557644 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHB1_HUMAN (4-778): 0: 575: 17.73
+	Hs
		208997 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA8_HUMAN (4-763): 0: 549: 19.79
+	Hs
		209065 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK2_HUMAN (114-757): 9.58e-166: 502: 25.84
+	Hs
		209063 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24
+	Hs
		208998 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		UFO_HUMAN (5-793): 5.98e-159: 486: 22.59
+	Hs
		557705 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24
+	Rn
		71362 B2RZ33_RAT (1-379): 7.98e-91: 279: 68.50		NTRK2_RAT (122-757): 1.27e-165: 501: 26.62
+	Hs
		384213 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		208976 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		434130 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		208982 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		KIT_HUMAN (454-785): 1.44e-68: 246: 37.62
+	Hs
		499225 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		KIT_HUMAN (454-785): 1.44e-68: 246: 37.62
+	Hs
		557625 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		VGFR2_HUMAN (74-376): 3.42e-24: 111: 16.67
+	Hs
		557624 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		VGFR3_HUMAN (153-356): 9.15e-11: 67.8: 18.78