HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	12470648
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0007165 - signal transduction GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 894
+	Hs
		209018 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA4_HUMAN (2-836): 0: 637: 19.40
+	Hs
		208996 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		557643 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHA5_HUMAN (2-812): 0: 622: 20.39
+	Hs
		557644 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHB1_HUMAN (2-833): 0: 621: 20.70
+	Hs
		208997 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA8_HUMAN (2-824): 0: 590: 19.20
+	Rn
		88904 D4A3M8_RAT (1-380): 3.21e-98: 298: 95.79		INSR_RAT (276-851): 1.26e-134: 437: 27.83
+	Hs
		411329 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Mm
		546262 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		INSR_MOUSE (232-851): 2.75e-135: 439: 26.37
+	Hs
		208977 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		441422 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		209036 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		557666 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Mm
		337637 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		ABL1_MOUSE (531-847): 2.2e-55: 210: 40.91
+	Hs
		208983 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69
+	Hs
		435526 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		782778 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		601605 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		FGFR2_HUMAN (27-239): 5.42e-33: 139: 14.46
+	Hs
		435570 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		508233 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69