HitPredict

Interactor 1: TGFI1 (O43294)
Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)
Gene: TGFB1I1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	37219487
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 1319
+	Hs
		861795 PDLI7_HUMAN (343-461): 1.74e-35: 138: 34.45		NEDD4_HUMAN (1-1319): 0: 1940: 100.00
+	Hs
		212733 TGFI1_HUMAN (1-461): 3.52e-97: 301: 100.00		NED4L_HUMAN (424-676): 1.65e-30: 133: 16.55
+	Mm
		1223900 TGFI1_MOUSE (1-461): 3.41e-96: 298: 91.32		ITCH_MOUSE (424-799): 2.39e-31: 135: 15.39
+	Hs
		212732 TGFI1_HUMAN (1-461): 3.52e-97: 301: 100.00		ITCH_HUMAN (305-642): 6.68e-25: 114: 14.82
+	Hs
		1430209 PDLI7_HUMAN (343-461): 1.74e-35: 138: 34.45		WWP1_HUMAN (385-707): 7.2e-57: 216: 17.48
+	Hs
		132321 PDLI7_HUMAN (343-461): 1.74e-35: 138: 34.45		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		1438980 PDLI7_HUMAN (343-461): 1.74e-35: 138: 34.45		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		870166 LIMS1_HUMAN (343-458): 2.91e-25: 107: 33.05		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		1123128 FHL2_HUMAN (199-337): 5.88e-24: 103: 23.78		SMUF2_HUMAN (485-719): 4.19e-24: 111: 18.55