HitPredict

Interactor 1: SAHH2 (O43865)
S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)
Gene: AHCYL1

Interactor 2: SAHH (P23526)
Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)
Gene: AHCY

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AdoHcyase~AdoHcyase, AdoHcyase~AdoHcyase_NAD, AdoHcyase_NAD~AdoHcyase_NAD
Common GO terms	GO:0005829 - cytosol GO:0006730 - one-carbon metabolic process GO:0033353 - S-adenosylmethionine cycle GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 432
+	Hs
		617884 SAHH3_HUMAN (7-530): 0: 879: 86.43		SAHH_HUMAN (1-432): 0: 774: 100.00
+	Hs
		216564 SAHH2_HUMAN (1-530): 0: 909: 100.00		SAHH3_HUMAN (7-432): 0: 727: 50.35
+	Hs
		216401 SAHH2_HUMAN (1-530): 0: 909: 100.00		SAHH2_HUMAN (7-432): 0: 700: 50.82
+	Dm
		1099902 SAHH2_DROME (57-530): 0: 794: 77.36		SAHH_DROME (4-432): 0: 737: 80.47
+	Hs
		617803 SAHH_HUMAN (105-530): 0: 727: 50.82		SAHH_HUMAN (1-432): 0: 774: 100.00
+	Dm
		1376013 SAHH2_DROME (57-530): 0: 794: 77.36		SAHH2_DROME (7-432): 0: 704: 51.40
+	Dm
		838429 SAHH2_DROME (57-530): 0: 794: 77.36		SAHH3_DROME (7-432): 0: 683: 50.94
+	Dm
		1099894 SAHH_DROME (99-530): 0: 726: 52.07		SAHH_DROME (4-432): 0: 737: 80.47
+	Zm
		85877 C0PHR4_MAIZE (95-530): 0: 690: 46.06		C0PHR4_MAIZE (7-432): 0: 675: 56.99
+	Ph
		223399 SAHH_PYRHO (102-515): 0: 590: 36.87		SAHH_PYRHO (7-417): 0: 581: 46.72