Protein: EZH2
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2)

Gene: EZH2
Organism: Mus musculus
Interactions: 64
UniProt ID: Q61188

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222442

EED
Polycomb protein EED

11

20

Small-scale

0.978

High

1222434

SUZ12
Polycomb protein Suz12

9

11

Small-scale

0.970

High

1222060

RBBP4
Histone-binding protein RBBP4

3

20

Small-scale

0.847

High

1222088

RBBP7
Histone-binding protein RBBP7

2

20

Small-scale

0.789

High

1222428

JARD2
Protein Jumonji

6

18

Small-scale

0.732

High

1222429

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.691

High

1222438

TRI35
E3 ubiquitin-protein ligase TRIM35

1

6

Small-scale

0.691

High

1222454

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

18

Small-scale

0.665

High

1036631

MTF2
Metal-response element-binding transcription factor 2

3

20

Small-scale

0.656

High

1222456

AEBP2
Zinc finger protein AEBP2

3

17

Small-scale

0.656

High

1000268

EZH1
Histone-lysine N-methyltransferase EZH1

1

19

Small-scale

0.618

High

1204118

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

16

Small-scale

0.618

High

1222424

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.618

High

148696

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.601

High

568887

DNMT1
DNA

2

19

Small-scale

0.601

High

1222446

DNM3L
DNA

1

13

Small-scale

0.586

High

1222447

PHF19
PHD finger protein 19

2

20

Small-scale

0.584

High

117095

J3QPN0
Zinc finger protein 518B

1

14

Small-scale

0.561

High

1222426

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.561

High

59527

SETX
Probable helicase senataxin

1

7

Small-scale

0.536

High

877623

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

13

Small-scale

0.536

High

1222435

NANOG
Homeobox protein NANOG

1

14

High-throughput

0.536

High

1222441

STK38
Serine/threonine-protein kinase 38

1

7

Small-scale

0.536

High

1017354

H33
Histone H3.3

1

20

Small-scale

0.527

High

1222453

CITE4
Cbp/p300-interacting transactivator 4

1

0

High-throughput

0.518

High

1222452

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

Small-scale

0.500

High

518513

MYOD1
Myoblast determination protein 1

1

5

Small-scale

0.481

High

73951

Z518A
Zinc finger protein 518A

1

13

Small-scale

0.479

High

108685

G3X9H5
Huntingtin

1

2

Small-scale

0.479

High

148277

CLOCK
Circadian locomoter output cycles protein kaput

1

10

Small-scale

0.479

High

312022

WIZ
Protein Wiz

1

13

Small-scale

0.479

High

534018

H10
Histone H1.0

1

1

Small-scale

0.479

High

662971

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

1021865

CRY1
Cryptochrome-1

1

1

Small-scale

0.479

High

1023453

ARVC
Splicing regulator ARVCF

1

9

Small-scale

0.479

High

1058809

H1T
Histone H1t

1

20

Small-scale

0.479

High

1222425

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.479

High

1222427

SSXT
Protein SSXT

1

14

Small-scale

0.479

High

1222430

RBL2
Retinoblastoma-like protein 2

1

9

Small-scale

0.479

High

1222431

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

4

Small-scale

0.479

High

1222432

LCOR
Ligand-dependent corepressor

1

5

Small-scale

0.479

High

1222433

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

1

5

Small-scale

0.479

High

1222437

ASXL2
Putative Polycomb group protein ASXL2

1

11

Small-scale

0.479

High

1222445

FOXP3
Forkhead box protein P3

1

4

Small-scale

0.479

High

1222448

Q9DCC5
Cbx3 protein

1

20

Small-scale

0.479

High

1222449

CUL3
Cullin-3

1

13

Small-scale

0.479

High

1222451

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

12

Small-scale

0.479

High

1222455

PHF1
PHD finger protein 1

1

20

Small-scale

0.479

High

1222439

H1FNT
Testis-specific H1 histone

1

0

Small-scale

0.458

High

312425

DNM3A
DNA

1

15

Small-scale

0.445

High

312441

DNM3B
DNA

1

15

Small-scale

0.445

High

1027938

TYY1
Transcriptional repressor protein YY1

1

12

Small-scale

0.445

High

1222444

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

2

Small-scale

0.445

High

107973

G3UWZ0
Bromodomain adjacent to zinc finger domain protein 1A

1

20

Small-scale

0.437

High

237294

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

Small-scale

0.437

High

920759

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

7

Small-scale

0.437

High

1025672

HMMR
Hyaluronan mediated motility receptor

1

8

Small-scale

0.437

High

1189903

Q3U3J1
2-oxoisovalerate dehydrogenase subunit alpha

1

3

Small-scale

0.437

High

1222440

NOC3L
Nucleolar complex protein 3 homolog

1

2

Small-scale

0.437

High

1222443

DDX27
Probable ATP-dependent RNA helicase DDX27

1

9

Small-scale

0.437

High

1222450

MY18A
Unconventional myosin-XVIIIa

1

6

Small-scale

0.437

High

104776

MORC3
MORC family CW-type zinc finger protein 3

1

0

Small-scale

0.426

High

1222436

VANG1
Vang-like protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025