HitPredict

Interactor 1: TYOBP (O43914)
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)
Gene: TYROBP

Interactor 2: TREM1 (Q9NP99)
Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)
Gene: TREM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	10799849, 11602640
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0035556 - intracellular signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 113 Hs			1 234
+	Mm
		222482 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		Q8BNV8_MOUSE (19-232): 2.46e-55: 178: 28.97
+	Mm
		222481 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		CLM4_MOUSE (2-185): 5.32e-52: 169: 25.00
+	Hs
		217292 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		NCTR2_HUMAN (27-226): 1.03e-44: 152: 24.16
+	Hs
		217311 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM6_HUMAN (4-185): 3.85e-44: 149: 19.36
+	Hs
		217328 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM5_HUMAN (21-174): 2.39e-41: 141: 21.29
+	Hs
		3044 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CD3CH_HUMAN (2-158): 5.32e-40: 138: 19.53
+	Hs
		66493 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM7_HUMAN (20-147): 1.92e-39: 136: 19.85
+	Hs
		217366 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		TREM2_HUMAN (9-166): 3.24e-38: 134: 22.35
+	Mm
		222485 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		TREM3_MOUSE (15-141): 1.91e-33: 120: 34.65