HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 537
+	Hs
		217431 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		217417 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Hs
		412314 UHRF2_HUMAN (287-410): 6.73e-27: 117: 24.22		FYN_HUMAN (1-537): 0: 643: 100.00
+	Hs
		522990 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		442831 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		HCK_HUMAN (1-535): 0: 548: 56.64
+	Hs
		442859 CHD5_HUMAN (288-504): 6.06e-28: 121: 17.41		HCK_HUMAN (1-535): 0: 548: 56.64
+	Hs
		411825 UHRF2_HUMAN (287-410): 6.73e-27: 117: 24.22		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		442819 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		HCK_HUMAN (1-535): 0: 548: 56.64
+	Ce
		106666 Q18605_CAEEL (233-475): 2.96e-39: 155: 20.30		SRC1_CAEEL (1-535): 5.09e-173: 500: 49.63
+	Hs
		433951 UHRF2_HUMAN (287-410): 6.73e-27: 117: 24.22		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		331700 NSD2_HUMAN (30-345): 3.09e-17: 87.5: 14.80		LYN_HUMAN (1-535): 0: 535: 54.48