HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 636
+	Mm
		665773 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		PABP1_MOUSE (1-636): 0: 581: 99.69
+	Hs
		516522 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		516483 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		516745 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		1031332 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		516645 NSD1_HUMAN (285-383): 1.69e-11: 69.4: 30.69		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		1018458 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Sc
		376840 JHD2_YEAST (287-341): 3.21e-10: 64.7: 43.10		PABP_YEAST (2-335): 1.06e-64: 225: 26.71
+	Hs
		582297 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		582257 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		331720 NSD2_HUMAN (30-345): 3.09e-17: 87.5: 14.80		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33