HitPredict

Interactor 1: SIM2 (Q14190)
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)
Gene: SIM2

Interactor 2: FOXR2 (Q6PJQ5)
Forkhead box protein R2 (Forkhead box protein N6)
Gene: FOXR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 311
+	Hs
		649126 ARNT_HUMAN (2-576): 5.63e-105: 338: 16.72		FOXR2_HUMAN (1-311): 8.15e-147: 416: 100.00
+	Hs
		175969 SIM2_HUMAN (1-667): 0: 541: 100.00		FOXN1_HUMAN (114-309): 6.54e-49: 174: 28.57
+	Mm
		725296 HIF1A_MOUSE (2-525): 3.97e-129: 403: 31.11		FOXA2_MOUSE (136-291): 1.01e-47: 167: 16.67
+	Mm
		725294 ARNT_MOUSE (2-588): 3.75e-108: 346: 17.29		FOXA2_MOUSE (136-291): 1.01e-47: 167: 16.67
+	Hs
		175956 ARNT_HUMAN (2-576): 5.63e-105: 338: 16.72		FOXN1_HUMAN (114-309): 6.54e-49: 174: 28.57
+	Hs
		952861 NPAS1_HUMAN (2-494): 3.68e-101: 322: 31.60		FOXK1_HUMAN (92-302): 2.6e-52: 184: 21.86
+	Hs
		964240 NPAS1_HUMAN (2-494): 3.68e-101: 322: 31.60		FOXK2_HUMAN (92-302): 9.84e-49: 174: 20.76
+	Ce
		108108 HIF1_CAEEL (2-644): 1.87e-94: 308: 18.72		PHA4_CAEEL (142-308): 3.52e-48: 169: 16.20