HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 248
+	Hs
		217429 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Mm
		1161053 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		SRSF1_MOUSE (1-235): 1.04e-49: 165: 100.00
+	Mm
		665773 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		PABP1_MOUSE (8-203): 8.27e-38: 141: 16.67
+	Hs
		217469 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Mm
		952212 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		SRSF3_MOUSE (15-99): 9.33e-28: 105: 43.53
+	Hs
		1028548 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Hs
		1028656 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		1028915 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		1018454 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		1018455 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		992774 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		992741 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		516522 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516483 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		951965 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		1059643 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		951935 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		1018508 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		1031332 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Hs
		1018458 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67