HitPredict

Interactor 1: RAD50 (O44199)
DNA repair protein rad-50 (EC 3.6.-.-)
Gene: rad-50

Interactor 2: MRE11 (Q23255)
Double-strand break repair protein mre-11
Gene: mre-11

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	12679813, 29686104, 31345995, 11778048, 14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA_23~Metallophos, AAA_23~Mre11_DNA_bind
Common GO terms	GO:0030870 - Mre11 complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1298 Ce			1 728
+	Mm
		936706 RAD50_MOUSE (1-1282): 3.92e-78: 285: 21.40		MRE11_MOUSE (55-719): 0: 741: 35.46
+	At
		1352506 RAD50_ARATH (1-1281): 4.28e-82: 297: 20.96		MRE11_ARATH (58-723): 0: 625: 32.11
+	Hs
		837057 RAD50_HUMAN (508-1283): 6.78e-19: 95.6: 8.21		MRE11_HUMAN (55-718): 0: 736: 34.72
+	Dm
		1376387 RAD50_DROME (1-1282): 5.15e-57: 219: 20.47		Q9XYZ4_DROME (54-684): 0: 601: 31.84
+	Sc
		521122 RAD50_YEAST (424-1296): 1.03e-15: 85.2: 10.18		MRE11_YEAST (62-704): 0: 626: 29.54