HitPredict

Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9489702, 12186560
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0008180 - COP9 signalosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 217
+	Hs
		220367 LAT_HUMAN (1-262): 1.61e-153: 429: 100.00		GRB2_HUMAN (1-216): 1.09e-69: 214: 59.72
+	Hs
		220338 LAT_HUMAN (1-262): 1.61e-153: 429: 100.00		FYN_HUMAN (3-217): 2.02e-40: 146: 24.17
+	Hs
		220337 LAT_HUMAN (1-262): 1.61e-153: 429: 100.00		LCK_HUMAN (4-204): 3.75e-35: 131: 26.05
+	Hs
		220347 LAT_HUMAN (1-262): 1.61e-153: 429: 100.00		VAV_HUMAN (2-60): 2.15e-16: 79.2: 33.90
+	Hs
		220328 LAT_HUMAN (1-262): 1.61e-153: 429: 100.00		GRAP2_HUMAN (3-55): 1.73e-11: 64: 33.96
+	Mm
		236831 LAT_MOUSE (24-262): 7.36e-91: 270: 59.44		GRB2_MOUSE (1-216): 9.27e-70: 214: 59.72
+	Mm
		236856 LAT_MOUSE (24-262): 7.36e-91: 270: 59.44		GRAP_MOUSE (1-217): 1.25e-63: 198: 92.17
+	Mm
		236812 LAT_MOUSE (24-262): 7.36e-91: 270: 59.44		FYN_MOUSE (3-217): 2.1e-40: 146: 24.17
+	Mm
		236809 LAT_MOUSE (24-262): 7.36e-91: 270: 59.44		VAV_MOUSE (2-60): 1.47e-16: 79.6: 33.90