HitPredict

Interactor 1: XPOT (O43592)
Exportin-T (Exportin(tRNA)) (tRNA exportin)
Gene: XPOT

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	32296183, 12138183, 11024021, 10944119, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Exportin-T~Ras, IBN_N~Ras, Ras~Xpo1
Common GO terms	GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 962 Hs			1 216
+	Sp
		313553 XPOT_SCHPO (2-961): 4.74e-151: 474: 25.23		SPI1_SCHPO (1-214): 1.07e-83: 249: 80.84
+	Hs
		172670 XPO1_HUMAN (1-961): 1.34e-151: 477: 14.33		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Sc
		721797 XPO1_YEAST (1-961): 2.82e-132: 427: 13.43		GSP1_YEAST (1-214): 1.88e-96: 281: 80.56
+	Dm
		1485211 Q9VRV8_DROME (2-953): 2.32e-123: 398: 12.24		RANL_DROME (1-210): 2.57e-93: 273: 60.48
+	At
		836666 MOS14_ARATH (2-942): 7.48e-114: 374: 13.62		RAN1_ARATH (1-216): 7.47e-96: 280: 73.52
+	Hs
		981621 TNPO1_HUMAN (10-919): 8.01e-129: 413: 12.88		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Hs
		164559 TNPO2_HUMAN (10-919): 8.31e-122: 394: 12.34		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	At
		836667 TNPO1_ARATH (1-855): 9.24e-106: 351: 13.35		RAN1_ARATH (1-216): 7.47e-96: 280: 73.52
+	Sc
		745689 XPOT_YEAST (10-961): 2.57e-103: 349: 17.72		GSP1_YEAST (1-214): 1.88e-96: 281: 80.56
+	Sc
		745931 MTR10_YEAST (3-957): 3.19e-100: 338: 14.80		GSP1_YEAST (1-214): 1.88e-96: 281: 80.56
+	At
		836671 IMB1_ARATH (1-880): 4.82e-100: 335: 11.53		RAN1_ARATH (1-216): 7.47e-96: 280: 73.52
+	Hs
		318129 IPO13_HUMAN (2-961): 2.28e-110: 365: 12.77		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	At
		836678 IMB1_ARATH (1-880): 4.82e-100: 335: 11.53		RAN2_ARATH (1-215): 8.76e-89: 262: 74.77
+	Sc
		745935 XPOT_YEAST (10-961): 2.57e-103: 349: 17.72		GSP2_YEAST (1-214): 2.6e-80: 240: 79.72
+	Hs
		981703 XPO5_HUMAN (1-879): 3.26e-103: 350: 13.26		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Hs
		976572 XPO5_HUMAN (1-879): 3.26e-103: 350: 13.26		RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67
+	At
		1300601 IMB1_ARATH (1-880): 4.82e-100: 335: 11.53		RAN3_ARATH (1-215): 7.37e-83: 247: 74.31
+	Sc
		745957 MTR10_YEAST (3-957): 3.19e-100: 338: 14.80		GSP2_YEAST (1-214): 2.6e-80: 240: 79.72
+	Hs
		981654 XPO6_HUMAN (13-957): 5.45e-85: 298: 11.17		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00