HitPredict

Interactor 1: TNPO2 (O14787)
Transportin-2 (Karyopherin beta-2b)
Gene: TNPO2

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.897

Property	Details
Experiments	12384575, 35271311, 32296183, unassigned1304
Identification Methods	pull down, affinity chromatography technology, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 897 Hs			1 216
+	Dm
		1485211 Q9VRV8_DROME (1-897): 0: 620: 71.46		RANL_DROME (1-210): 2.57e-93: 273: 60.48
+	Hs
		981621 TNPO1_HUMAN (2-897): 0: 629: 84.39		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	At
		836667 TNPO1_ARATH (3-895): 2.81e-171: 522: 42.90		RAN1_ARATH (1-216): 7.47e-96: 280: 73.52
+	At
		836671 IMB1_ARATH (9-851): 1.32e-103: 343: 15.21		RAN1_ARATH (1-216): 7.47e-96: 280: 73.52
+	Sc
		745716 IMB2_YEAST (2-894): 1.45e-102: 341: 30.25		GSP1_YEAST (1-214): 1.88e-96: 281: 80.56
+	At
		836678 IMB1_ARATH (9-851): 1.32e-103: 343: 15.21		RAN2_ARATH (1-215): 8.76e-89: 262: 74.77
+	At
		1300601 IMB1_ARATH (9-851): 1.32e-103: 343: 15.21		RAN3_ARATH (1-215): 7.37e-83: 247: 74.31
+	Sc
		745938 IMB2_YEAST (2-894): 1.45e-102: 341: 30.25		GSP2_YEAST (1-214): 2.6e-80: 240: 79.72
+	Hs
		981493 IMB1_HUMAN (11-871): 4.15e-93: 315: 17.72		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Sc
		745880 IMB1_YEAST (12-839): 3.1e-76: 268: 14.56		GSP1_YEAST (1-214): 1.88e-96: 281: 80.56
+	Hs
		934050 XPO2_HUMAN (3-896): 3.35e-91: 311: 13.62		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Hs
		189141 IPO8_HUMAN (10-847): 7.28e-87: 301: 14.44		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Hs
		334737 IPO7_HUMAN (11-854): 5.98e-78: 276: 13.19		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Sc
		734638 IMB3_YEAST (7-612): 1.26e-33: 141: 17.08		GSP1_YEAST (1-214): 1.88e-96: 281: 80.56
+	Hs
		981604 IPO4_HUMAN (23-761): 3.86e-35: 146: 17.15		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Sc
		734639 IMB3_YEAST (7-612): 1.26e-33: 141: 17.08		GSP2_YEAST (1-214): 2.6e-80: 240: 79.72
+	Dm
		197105 Q9VN44_DROME (7-895): 9.49e-32: 135: 11.54		O18332_DROME (1-207): 2.11e-80: 240: 26.07
+	Hs
		134001 IPO5_HUMAN (20-627): 3.4e-15: 82.3: 10.62		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Hs
		251207 RNBP6_HUMAN (11-549): 9.88e-14: 77.7: 12.42		RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67